Effectiveness of Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccines Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in a Cohort of Healthcare Personnel

被引:35
作者
Swift, Melanie D. [1 ]
Breeher, Laura E. [1 ]
Tande, Aaron J. [2 ]
Tommaso, Christopher P. [3 ]
Hainy, Caitlin M. [1 ]
Chu, Haitao [4 ]
Murad, M. Hassan [1 ]
Berbari, Elie F. [2 ]
Virk, Abinash [2 ]
机构
[1] Mayo Clin, Div Prevent Occupat & Aerosp Med, Rochester, MN 55905 USA
[2] Mayo Clin, Div Infect Dis, Rochester, MN 55905 USA
[3] Mayo Clin, Occupat Hlth Serv, Rochester, MN 55905 USA
[4] Univ Minnesota Twin Cities, Div Biostat, Minneapolis, MN USA
关键词
COVID-19; SARS-CoV-2; vaccine effectiveness; healthcare personnel; mRNA;
D O I
10.1093/cid/ciab361
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In a large cohort of United States healthcare personnel without prior coronavirus disease 2019 (COVID-19) infection, 94 382 doses of messenger RNA (mRNA) COVID-19 vaccine were administered to 49 220 individuals. The adjusted vaccine effectiveness following 2 doses of each of the 2 available brands of mRNA vaccine exceeded 96%.
引用
收藏
页码:E1376 / E1379
页数:4
相关论文
共 10 条
[1]   Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients [J].
Amit, Sharon ;
Regev-Yochay, Gili ;
Afek, Arnon ;
Kreiss, Yitshak ;
Leshem, Eyal .
LANCET, 2021, 397 (10277) :875-877
[2]   Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine [J].
Baden, Lindsey R. ;
El Sahly, Hana M. ;
Essink, Brandon ;
Kotloff, Karen ;
Frey, Sharon ;
Novak, Rick ;
Diemert, David ;
Spector, Stephen A. ;
Rouphael, Nadine ;
Creech, C. Buddy ;
McGettigan, John ;
Khetan, Shishir ;
Segall, Nathan ;
Solis, Joel ;
Brosz, Adam ;
Fierro, Carlos ;
Schwartz, Howard ;
Neuzil, Kathleen ;
Corey, Larry ;
Gilbert, Peter ;
Janes, Holly ;
Follmann, Dean ;
Marovich, Mary ;
Mascola, John ;
Polakowski, Laura ;
Ledgerwood, Julie ;
Graham, Barney S. ;
Bennett, Hamilton ;
Pajon, Rolando ;
Knightly, Conor ;
Leav, Brett ;
Deng, Weiping ;
Zhou, Honghong ;
Han, Shu ;
Ivarsson, Melanie ;
Miller, Jacqueline ;
Zaks, Tal .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) :403-416
[3]   A Framework for Sustainable Contact Tracing and Exposure Investigation for Large Health Systems [J].
Breeher, Laura ;
Boon, Ashton ;
Hainy, Caitlin ;
Murad, M. Hassan ;
Wittich, Christopher ;
Swift, Melanie .
MAYO CLINIC PROCEEDINGS, 2020, 95 (07) :1432-1444
[4]  
Chu Haitao, 2004, Clin Trials, V1, P306, DOI 10.1191/1740774504cn025oa
[5]   BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting [J].
Dagan, Noa ;
Barda, Noam ;
Kepten, Eldad ;
Miron, Oren ;
Perchik, Shay ;
Katz, Mark A. ;
Hernan, Miguel A. ;
Lipsitch, Marc ;
Reis, Ben ;
Balicer, Ran D. .
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (15) :1412-1423
[6]   An interactive web-based dashboard to track COVID-19 in real time [J].
Dong, Ensheng ;
Du, Hongru ;
Gardner, Lauren .
LANCET INFECTIOUS DISEASES, 2020, 20 (05) :533-534
[7]  
Dooling K, 2020, MMWR-MORBID MORTAL W, V69, P1857, DOI [10.15585/mmwr.mm6949e1, 10.15585/mmwr.mm695152e2]
[8]   COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study [J].
Hall, Victoria Jane ;
Foulkes, Sarah ;
Saei, Ayoub ;
Andrews, Nick ;
Oguti, Blanche ;
Charlett, Andre ;
Wellington, Edgar ;
Stowe, Julia ;
Gillson, Natalie ;
Atti, Ana ;
Islam, Jasmin ;
Karagiannis, Ioannis ;
Munro, Katie ;
Khawam, Jameel ;
Chand, Meera A. ;
Brown, Colin S. ;
Ramsay, Mary ;
Lopez-Bernal, Jamie ;
Hopkins, Susan .
LANCET, 2021, 397 (10286) :1725-1735
[9]   Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine [J].
Polack, Fernando P. ;
Thomas, Stephen J. ;
Kitchin, Nicholas ;
Absalon, Judith ;
Gurtman, Alejandra ;
Lockhart, Stephen ;
Perez, John L. ;
Perez Marc, Gonzalo ;
Moreira, Edson D. ;
Zerbini, Cristiano ;
Bailey, Ruth ;
Swanson, Kena A. ;
Roychoudhury, Satrajit ;
Koury, Kenneth ;
Li, Ping ;
Kalina, Warren V. ;
Cooper, David ;
Frenck, Robert W., Jr. ;
Hammitt, Laura L. ;
Tureci, Ozlem ;
Nell, Haylene ;
Schaefer, Axel ;
Unal, Serhat ;
Tresnan, Dina B. ;
Mather, Susan ;
Dormitzer, Philip R. ;
Sahin, Ugur ;
Jansen, Kathrin U. ;
Gruber, William C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (27) :2603-2615
[10]  
Swift MD, NEJM CATAL, V2021, P1