Trans-Plasma Membrane Electron Transport in Mammals: Functional Significance in Health and Disease

被引：37

作者：

Del Principe, Domenico ^{[1
,2
]}

Avigliano, Luciana ^{[1
]}

Savini, Isabella ^{[1
]}

Catani, Maria Valeria ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dept Expt Med & Biochem Sci, I-00133 Rome, Italy

[2] Ist Sci Biomed S Raffaele, Sulmona, Italy

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2011年 / 14卷 / 11期

关键词：

CYTOCHROME B(5) REDUCTASE; NADH OXIDASE ACTIVITY; NICOTINAMIDE ADENINE-DINUCLEOTIDE; DEPENDENT ANION CHANNELS; CHRONIC GRANULOMATOUS-DISEASE; SURFACE OXYGEN-CONSUMPTION; FREE-RADICAL REDUCTASE; REDOX SYSTEM ACTIVITY; SMOOTH-MUSCLE-CELLS; ALPHA-LIPOIC ACID;

D O I：

10.1089/ars.2010.3247

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trans-plasma membrane electron transport (t-PMET) has been established since the 1960s, but it has only been subject to more intensive research in the last decade. The discovery and characterization at the molecular level of its novel components has increased our understanding of howt-PMET regulates distinct cellular functions. This review will give an update on t-PMET, with particular emphasis on how its malfunction relates to some diseases, such as cancer, abnormal cell death, cardiovascular diseases, aging, obesity, neurodegenerative diseases, pulmonary fibrosis, asthma, and genetically linked pathologies. Understanding these relationships may provide novel therapeutic approaches for pathologies associated with unbalanced redox state. Antioxid. Redox Signal. 14, 2289-2318.

引用

页码：2289 / 2318

页数：30

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