Selective IgA Deficiency in Autoimmune Diseases

被引：143

作者：

Wang, Ning ^{[1
]}

Shen, Nan ^{[2
]}

Vyse, Timothy J. ^{[3
]}

Anand, Vidya ^{[3
]}

Gunnarson, Iva ^{[4
]}

Sturfelt, Gunnar ^{[5
]}

Rantapaa-Dahlqvist, Solbritt ^{[6
]}

Elvin, Kerstin ^{[7
]}

Truedsson, Lennart ^{[8
]}

Andersson, Bengt A. ^{[9
]}

Dahle, Charlotte ^{[10
]}

Ortqvist, Eva ^{[11
]}

Gregersen, Peter K. ^{[12
]}

Behrens, Timothy W. ^{[13
]}

Hammarstrom, Lennart ^{[1
]}

机构：

[1] Karolinska Inst, Karolinska Univ Hosp Huddinge, Div Clin Immunol, Dept Lab Med, S-14186 Stockholm, Sweden

[2] Jiao Tong Univ, Sch Med, Dept Rheumatol, Renji Hosp, Shanghai 200030, Peoples R China

[3] Hammersmith Hosp, Sect Mol Genet & Rheumatol, London, England

[4] Karolinska Univ Hosp Solna, Dept Med, Rheumatol Unit, Stockholm, Sweden

[5] Univ Lund Hosp, Dept Rheumatol, S-22185 Lund, Sweden

[6] Umea Univ Hosp, Dept Rheumatol, S-90185 Umea, Sweden

[7] Karolinska Univ Hosp Huddinge, Dept Clin Immunol & Transfus Med, Unit Clin Immunol, Stockholm, Sweden

[8] Lund Univ, Dept Lab Med, Sect Microbiol Immunol & Glycobiol, S-22100 Lund, Sweden

[9] Sahlgrens Acad, Dept Immunol, Gothenburg, Sweden

[10] Linkoping Univ, Clin Immunol Unit, Dept Clin & Expt Med, Linkoping, Sweden

[11] Karolinska Univ Hosp Solna, Astrid Lindgren Childrens Hosp, Dept Woman & Child Hlth, Stockholm, Sweden

[12] Feinstein Inst Med Res, Robert S Boas Ctr Genom & Human Genet, Manhasset, NY USA

[13] Genentech Inc, Div Immunol Tissue Growth & Repair Biomarker Disc, San Francisco, CA 94080 USA

来源：

MOLECULAR MEDICINE | 2011年 / 17卷 / 11-12期

基金：

瑞典研究理事会;

关键词：

SYSTEMIC-LUPUS-ERYTHEMATOSUS; JUVENILE RHEUMATOID-ARTHRITIS; MAJOR HISTOCOMPATIBILITY COMPLEX; IMMUNOGLOBULIN-A DEFICIENCY; GENOME-WIDE ASSOCIATION; DEPENDENT DIABETES-MELLITUS; ACETYLCHOLINE-RECEPTOR ANTIBODIES; ANTI-ENDOMYSIAL ANTIBODY; OF-THE-LITERATURE; CLASS-III REGION;

D O I：

10.2119/molmed.2011.00195

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D). celiac disease (CD), myasthenia gravis (MG) and rheumatoid arthritis (RA) on the basis of both our own recent large-scale screening results and literature data. Genetic factors are important for the development of both IgAD and various autoimmune disorders, including GD, SLE, T1D, CD, MG and RA, and a strong association with the major histocompatibility complex (MHC) region has been reported. In addition, non-MHC genes, such as interferon-induced helicase 1 (IFH1) and c-type lectin domain family 16, member A (CLEC16A), are also associated with the development of IgAD and some of the above diseases. This indicates a possible common genetic background. In this review, we present suggestive evidence for a shared genetic predisposition between these disorders. (C) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org Online address: hffp://www.molmed.org doi: 10.2119/molmed.2011.00195

引用

页码：1383 / 1396

页数：14

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