COVID-19 infection and rheumatoid arthritis: Faraway, so close!

被引：292

作者：

Favalli, Ennio Giulio ^{[1
]}

Ingegnoli, Francesca ^{[1
,2
]}

De Lucia, Orazio ^{[1
]}

Cincinelli, Gilberto ^{[2
]}

Cimaz, Rolando ^{[2
,3
]}

Caporali, Roberto ^{[1
,2
]}

机构：

[1] ASST Gaetano Pini, Div Clin Rheumatol, CTO Inst, Via Gaetano Pini 9, I-20122 Milan, Italy

[2] Univ Milan, Res Ctr Adult & Pediat Rheumat Dis, Dept Clin Sci & Community Hlth, Milan, Italy

[3] ASST Gaetano Pini, Div Pediat Rheumatol, CTO Inst, Milan, Italy

来源：

AUTOIMMUNITY REVIEWS | 2020年 / 19卷 / 05期

关键词：

Rheumatoid arthritis; COVID-19; Treatment; DMARDs; Cytokine release syndrome; Coronavirus; SERIOUS INFECTIONS; KINASE INHIBITORS; CONVERTING ENZYME; SPIKE PROTEIN; IN-VITRO; RISK; CORONAVIRUS; THERAPY; COHORT; METHOTREXATE;

D O I：

10.1016/j.autrev.2020.102523

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The outbreak of the new coronavirus infections COVID-19 in December 2019 in China has quickly become a global health emergency. Given the lack of specific anti-viral therapies, the current management of severe acute respiratory syndrome coronaviruses (SARS-CoV-2) is mainly supportive, even though several compounds are now under investigation for the treatment of this life-threatening disease. COVID-19 pandemic is certainly conditioning the treatment strategy of a complex disorder as rheumatoid arthritis (RA), whose infectious risk is increased compared to the general population because of an overall impairment of immune system typical of autoimmune diseases combined with the iatrogenic effect generated by corticosteroids and immunosuppressive drugs. However, the increasing knowledge about the pathophysiology of SARS-CoV-2 infection is leading to consider some anti-rheumatic drugs as potential treatment options for the management of COVID-19. In this review we will critically analyse the evidences on either positive or negative effect of drugs commonly used to treat RA in this particular scenario, in order to optimize the current approach to RA patients.

引用

页数：7

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