The Response of HIV-Associated Lymphadenopathic Kaposi Sarcoma to Highly Active Antiretroviral Therapy Evaluated by 18F-FDG PET/CT

被引：7
作者：
Mankia, Satveer K.
Miller, Robert F. [2 ]
Edwards, Simon G. [3 ]
Ramsay, Alan [4 ]
Lee, Siow Ming [1 ]
机构：
[1] Univ Coll London Hosp, Dept Oncol, London NW1 2PG, England
[2] UCL, Res Dept Infect & Populat Hlth, Ctr Sexual Hlth & HIV Res, London, England
[3] Camden Provider Serv, Mortimer Market Ctr, Dept Genitourinary Med, London, England
[4] UCL, Dept Histopathol, London, England
来源：
CLINICAL NUCLEAR MEDICINE | 2012年 / 37卷 / 07期
关键词：
Kaposi sarcoma; HIV; human herpes virus-8; PET/CT; HAART; chemotherapy; ERA;
D O I：
10.1097/RLU.0b013e3182485261
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The use of PET/CT for determining systemic Kaposi sarcoma (KS) involvement and treatment response remains to be formally assessed. Pretreatment human herpes virus-8 (HHV-8) viral load may predict clinical response of KS to therapy; however, its role in treatment monitoring and correlation with PET/CT findings is unknown. We report PET/CT findings and HHV-8 viral loads of a 46-year-old man with HIV-associated lymphadenopathic KS. After treatment with highly active antiretroviral therapy, an interval PET/CT showed partial response, despite an undetectable HHV-8 viral load. Chemotherapy was initiated, and the patient achieved a complete clinical, PET/CT, and virological response. PET/CT enabled monitoring of treatment response and led to changes in management.
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收藏
页码：692 / 693
页数：2
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