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High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD
被引:11
作者:

van Nijnatten, Jos
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Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, COPD, Groningen, Netherlands
Univ Technol Sydney, Resp Bioinformat & Mol Biol, Sydney, NSW, Australia Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

Brandsma, Corry-Anke
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Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, COPD, Groningen, Netherlands Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

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Hiemstra, Pieter S.
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Leiden Univ, Dept Pulmonol, Med Ctr, Leiden, Netherlands Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands

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Faiz, Alen
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Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma, Groningen, Netherlands
Univ Groningen, Univ Med Ctr Groningen, COPD, Groningen, Netherlands
Univ Technol Sydney, Resp Bioinformat & Mol Biol, Sydney, NSW, Australia Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
机构:
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands
[2] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Dis, Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma, Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, COPD, Groningen, Netherlands
[5] Univ Technol Sydney, Resp Bioinformat & Mol Biol, Sydney, NSW, Australia
[6] Boston Univ, Bioinformat Program, Boston, MA 02215 USA
[7] Boston Univ, Sch Med, Sect Pulmlonary & Crit Care Med, Boston, MA 02118 USA
[8] Leiden Univ, Dept Pulmonol, Med Ctr, Leiden, Netherlands
关键词:
T-CELL-ACTIVATION;
GENE-EXPRESSION;
LUNG-CANCER;
E-CADHERIN;
DIFFERENTIATION;
SMOKING;
MICRORNA;
RECEPTOR;
INHIBITORS;
NETWORKS;
D O I:
10.1038/s41598-022-09093-0
中图分类号:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
Smoking is a leading cause of chronic obstructive pulmonary disease (COPD). It is known to have a significant impact on gene expression and (inflammatory) cell populations in the airways involved in COPD pathogenesis. In this study, we investigated the impact of smoking on the expression of miRNAs in healthy and COPD individuals. We aimed to elucidate the overall smoking-induced miRNA changes and those specific to COPD. In addition, we investigated the downstream effects on regulatory gene expression and the correlation to cellular composition. We performed a genome-wide miRNA expression analysis on a dataset of 40 current- and 22 ex-smoking COPD patients and a dataset of 35 current- and 38 non-smoking respiratory healthy controls and validated the results in an independent dataset. miRNA expression was then correlated with mRNA expression in the same patients to assess potential regulatory effects of the miRNAs. Finally, cellular deconvolution analysis was used to relate miRNAs changes to specific cell populations. Current smoking was associated with increased expression of three miRNAs in the COPD patients and 18 miRNAs in the asymptomatic smokers compared to respiratory healthy controls. In comparison, four miRNAs were lower expressed with current smoking in asymptomatic controls. Two of the three smoking-related miRNAs in COPD, miR-203a-3p and miR-375, were also higher expressed with current smoking in COPD patients and the asymptomatic controls. The other smoking-related miRNA in COPD patients, i.e. miR-31-3p, was not present in the respiratory healthy control dataset. miRNA-mRNA correlations demonstrated that miR-203a-3p, miR-375 and also miR-31-3p expression were negatively associated with genes involved in pro-inflammatory pathways and positively associated with genes involved in the xenobiotic pathway. Cellular deconvolution showed that higher levels of miR-203a-3p were associated with higher proportions of proliferating-basal cells and secretory (club and goblet) cells and lower levels of fibroblasts, luminal macrophages, endothelial cells, B-cells, amongst other cell types. MiR-375 expression was associated with lower levels of secretory cells, ionocytes and submucosal cells, but higher levels of endothelial cells, smooth muscle cells, and mast cells, amongst other cell types. In conclusion, we identified two smoking-induced miRNAs (miR-375 and miR-203a-3p) that play a role in regulating inflammation and detoxification pathways, regardless of the presence or absence of COPD. Additionally, in patients with COPD, we identified miR-31-3p as a miRNA induced by smoking. Our identified miRNAs should be studied further to unravel which smoking-induced inflammatory mechanisms are reactive and which are involved in COPD pathogenesis.
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Inst, Cambridge, EnglandKoppelman, Gerard H.论文数: 0 引用数: 0 h-index: 0机构: Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD, Groningen, Netherlands Univ Groningen, Univ Med Ctr Groningen, Beatrix Childrens Hosp, Dept Pediat Pulmonol & Pediat Allergol, Groningen, Netherlands Wellcome Sanger Inst, Cambridge, Englandvan Oosterhout, Antoon J.论文数: 0 引用数: 0 h-index: 0机构: GlaxoSmithKline, Allerg Inflammat Discovery Performance Unit, Resp Therapy Area, Stevenage, Herts, England Wellcome Sanger Inst, Cambridge, EnglandSchiller, Herbert B.论文数: 0 引用数: 0 h-index: 0机构: German Ctr Lung Res DZL, Inst Lung Biol & Dis, Helmholtz Zentrum Munchen, Munich, Germany Wellcome Sanger Inst, Cambridge, EnglandTheis, Fabian J.论文数: 0 引用数: 0 h-index: 0机构: Helmholtz Zentrum Munchen, Inst Computat Biol, Neuherberg, Germany Tech Univ Munich, Dept Math, Garching, Germany Wellcome Sanger Inst, Cambridge, England论文数: 引用数: h-index:机构:Nawijn, Martijn C.论文数: 0 引用数: 0 h-index: 0机构: Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, Groningen, Netherlands Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD, Groningen, Netherlands Wellcome Sanger Inst, Cambridge, EnglandTeichmann, Sarah A.论文数: 0 引用数: 0 h-index: 0机构: Wellcome Sanger Inst, Cambridge, England Open Targets, Cambridge, England Univ Cambridge, Dept Phys, Cavendish Lab, Condensed Matter Theory Grp, Cambridge, England Wellcome Sanger Inst, Cambridge, England
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