Enantioselective synthesis of 3,3′-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction

被引：48
作者：
Wei, Wen-Tao [1 ]
Chen, Chun-Xia [1 ]
Lu, Rui-Jiong [1 ]
Wang, Jin-Jia [1 ]
Zhang, Xue-Jing [1 ]
Yan, Ming [1 ]
机构：
[1] Sun Yat Sen Univ, Inst Drug Synth & Pharmaceut Proc, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2012年 / 10卷 / 27期
基金：
中国国家自然科学基金;
关键词：
MULTICOMPONENT REACTIONS; CONSTRUCTION; SPIROOXINDOLES; ISOCYANOESTERS; DOMINO; STEREOCENTERS; DISCOVERY;
D O I：
10.1039/c2ob25629k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An organocatalytic three-component reaction of isatins, malononitrile and isocyanoacetates provided 3,3'-dihydropyrryl-spirooxindoles in excellent yields and enantioselectivities. The products could be readily converted to valuable 3,3'-pyrrolidinyl-spirooxindoles.
引用
收藏
页码：5245 / 5252
页数：8
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