Stereoselective synthesis of Z-4-diethoxyphosphory1-2-hydroxymethyltetrahydrofuran

被引：1
作者：
Brel, V. K. [1 ,2 ]
机构：
[1] Russian Acad Sci, Inst Physiologically Act Cpds, Chernogolovka 142432, Moscow Region, Russia
[2] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2014年 / 63卷 / 05期
基金：
俄罗斯基础研究基金会;
关键词：
tetrahydrofurans; phosphonates; allenes; hydrogenation; stereoselective synthesis; CYCLIZATION;
D O I：
10.1007/s11172-014-0568-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrogenation of 2-benzyloxymethy1-4-diethoxyphosphory1-2-R-2,5-dihydrofurans in the case of R = Me gives a mixture of Z- and E-isomers (76 : 19) of 4-diethoxyphosphory1-2-hydroxymethy1-2-methyltetrahydrofuran, whereas in the case of R = H an individual Z-isomer is formed. E-Isomer predominates when a nonbenzylated analog is hydrogenated.
引用
收藏
页码：1178 / 1180
页数：3
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