In Vitro Antiviral Activity of Lutein against Hepatitis B Virus

被引：37

作者：

Pang, Ran ^{[1
]}

Tao, Jun-Yan ^{[2
]}

Zhang, Shu-Ling ^{[1
]}

Zhao, Lei ^{[1
]}

Yue, Xin ^{[2
]}

Wang, Yue-Feng ^{[1
]}

Ye, Pian ^{[1
]}

Dong, Ji-Hua ^{[3
]}

Zhu, Ying ^{[2
]}

Wu, Jian-Guo ^{[2
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Hepatol & Infect Dis, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

[2] Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan 430072, Peoples R China

[3] Huazhong Univ Sci & Technol, Cent Lab, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

来源：

PHYTOTHERAPY RESEARCH | 2010年 / 24卷 / 11期

关键词：

hepatitis B virus; lutein; HBsAg; HBeAg; HBV DNA; HBV promoter; RISK; CAROTENOIDS; PROTEIN; CELLS;

D O I：

10.1002/ptr.3155

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Despite the availability of an effective vaccine, the hepatitis B virus (HBV) infection and its treatment remains one of the foremost public health problems in the world. The present study was performed in order to investigate the anti-HBV activity of lutein in vitro. The antiviral activity of lutein was examined by detecting the levels of HBsAg, HBeAg and extracellular HBV DNA in stable HBV-producing human hepatoblastoma HepG2 2.2.15 cells. It was found that lutein effectively suppressed the secretion of HBsAg from HepG2 2.2.15 cells in a dose-dependent manner, and it also suppressed the amount of extracellular HBV DNA. A luciferase reporter gene assay was used to determine the effects of lutein on the activities of HBV promoters. The results showed that lutein inhibited the activity of HBV full-length promoter (Fp). These data indicate that lutein possesses an anti-HBV activity and exerts its antivirus effects via inhibition of HBV transcription. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：1627 / 1630

页数：4

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