Natural Killer Cells as Sensors of Adipose Tissue Stress

被引：31

作者：

Ferno, Johan ^{[1
,2
]}

Strand, Kristina ^{[1
,2
]}

Mellgren, Gunnar ^{[1
,2
]}

Stiglund, Natalie ^{[3
]}

Bjorkstrom, Niklas K. ^{[3
]}

机构：

[1] Haukeland Hosp, Hormone Lab, N-5021 Bergen, Norway

[2] Univ Bergen, Dept Clin Sci, Mohn Nutr Res Lab, Bergen, Norway

[3] Karolinska Inst, Ctr Infect Med, Karolinska Univ Hosp, Dept Med Huddinge, Stockholm, Sweden

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2020年 / 31卷 / 01期

基金：

瑞典研究理事会;

关键词：

OBESITY; INFLAMMATION; MACROPHAGES; NK; DYSFUNCTION; IMMUNITY; HOMEOSTASIS; HYPOXIA; SYSTEM; CANCER;

D O I：

10.1016/j.tem.2019.08.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adipose tissue macrophages (ATMs) orchestrate low-grade chronic adipose tissue inflammation, linking obesity and insulin resistance. Whereas factors contributing to macrophage accumulation in adipose tissue are established, little is known regarding signals that link adipocyte stress to proinflammatory activation of macrophages. Natural killer (NK) cells are specialized innate lymphocytes that identify and respond to stressed cells. In this Opinion, we discuss the possibility of NK cells to function as sensors recognizing adipose tissue stress. We further summarize recent literature suggesting NK cells to play an important role in development of insulin resistance via secretion of cytokines that stimulate proinflammatory polarization of ATMs. This suggests adipose tissue-resident NK cells as a pharmacological target for the treatment of obesity-induced insulin resistance.

引用

页码：3 / 12

页数：10

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