Histone deacetylases

被引：352
作者：
Marks, PA
Miller, T
Richon, VM
机构：
[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10021 USA
[2] Aton Pharma Inc, Tarrytown, NY USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 04期
关键词：
D O I：
10.1016/S1471-4892(03)00084-5
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Post-translational modification of the histories of chromatin has a fundamental role in regulating gene expression. Enzymes involved in these epigenetic events include histone deacetylases (class I and class II), which can be inhibited by a structurally diverse group of small molecules. These histone deacetylase inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. Results of clinical trials with several of these agents have indicated that they are well tolerated at doses that have anti-tumour activity.
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页码：344 / 351
页数：8
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