Observation of a rectangular DNA superlattice in the liquid-crystalline phase of cationic lipid/DNA complexes

被引：16
作者：
Caracciolo, Giulio
Pozzi, Daniela
Caminiti, Ruggero
Mancini, Giovanna
Luciani, Paola
Amenitsch, Heinz
机构：
[1] Univ Roma La Sapienza, Dept Chem, I-00185 Rome, Italy
[2] CNR, IMC, I-00185 Rome, Italy
[3] Austrian Acad Sci, Inst Biophys & Nanosyst Res, A-8042 Graz, Austria
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 33期
关键词：
D O I：
10.1021/ja073890s
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reported here is the thermotropic behavior of cationic gemini/phospholipid/DNA complexes investigated by synchrotron X-ray diffraction. At low temperature, DNA forms rectangular columnar superlattices between interdigitated bilayers. At temperatures above the lipid main phase transition, the transbilayer DNA ordering is partly preserved and DNA arranged into a simple rectangular lattice. This is the first time that such a predicted superstructure is observed in the liquid-crystalline phase of cationic lipid/DNA complexes.
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页码：10092 / +
页数：3
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