Fluorescence Quenching of Alpha-Fetoprotein by Gold Nanoparticles: Effect of Dielectric Shell on Non-Radiative Decay

被引：25

作者：

Zhu, Jian ^{[1
]}

Li, Jian-jun ^{[1
]}

Wang, A-qing ^{[1
]}

Chen, Yu ^{[1
]}

Zhao, Jun-wu ^{[1
]}

机构：

[1] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Minist Educ, Key Lab Biomed Informat Engn, Xian 710049, Peoples R China

来源：

NANOSCALE RESEARCH LETTERS | 2010年 / 5卷 / 09期

关键词：

Fluorescence quenching; Gold nanoparticles; Alpha-fetoprotein (AFP); Non-radiative decay; Dielectric shell; PHOTOLUMINESCENCE; IMMUNOSENSOR; MONOLAYERS; PARTICLES; RESONANCE;

D O I：

10.1007/s11671-010-9668-0

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Fluorescence quenching spectrometry was applied to study the interactions between gold colloidal nanoparticles and alpha-fetoprotein (AFP). Experimental results show that the gold nanoparticles can quench the fluorescence emission of adsorbed AFP effectively. Furthermore, the intensity of fluorescence emission peak decreases monotonously with the increasing gold nanoparticles content. A mechanism based on surface plasmon resonance-induced non-radiative decay was investigated to illuminate the effect of a dielectric shell on the fluorescence quenching ability of gold nanoparticles. The calculation results show that the increasing dielectric shell thickness may improve the monochromaticity of fluorescence quenching. However, high energy transfer efficiency can be obtained within a wide wavelength band by coating a thinner dielectric shell.

引用

页码：1496 / 1501

页数：6

共 29 条

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