Asymmetric transfer hydrogenation of ketones promoted by manganese(I) pre-catalysts supported by bidentate aminophosphines

被引：39

作者：

Azouzi, Karim ^{[1
]}

Bruneau-Voisine, Antoine ^{[1
,2
]}

Vendier, Laure ^{[1
]}

Sortais, Jean-Baptiste ^{[1
,3
]}

Bastin, Stephanie ^{[1
]}

机构：

[1] Univ Toulouse, UPS, CNRS, LCC CNRS, Toulouse, France

[2] Univ Rennes, CNRS, ISCR, UMR 6226, F-35000 Rennes, France

[3] Inst Univ France, 1 Rue Descartes, F-75231 Paris 05, France

来源：

CATALYSIS COMMUNICATIONS | 2020年 / 142卷 / 142期

关键词：

Manganese; Chiral aminophosphine ligands; Transfer hydrogenation; Reduction; Ketones; ENANTIOSELECTIVE HYDROGENATION; METAL-COMPLEXES; IRON; RUTHENIUM; ALDEHYDES;

D O I：

10.1016/j.catcom.2020.106040

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A series of commercially available chiral amino-phosphines, in combination with Mn(CO)(5)Br, has been evaluated for the asymmetric reduction of ketones, using isopropanol as hydrogen source. With the most selective ligand, the corresponding manganese complex was synthesized and fully characterized. A series of ketones (20 examples) was hydrogenated in the presence of 0.5 mol% of the manganese pre-catalyst at 30 degrees C, affording the chiral alcohols in high yields with enantiomeric excesses up to 99%.

引用

页数：6

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