Ferrocenyl bisoxazoline as an efficient non-phosphorus ligand for palladium-catalyzed copper-free Sonogashira reaction in aqueous solution

被引：6

作者：

Yu, Shuyan ^{[1
]}

Wu, Jingxin ^{[1
]}

He, Xinwei ^{[2
]}

Shang, Yongjia ^{[2
]}

机构：

[1] Zhengzhou Univ Light Ind, Mat & Chem Engn Coll, Zhengzhou 450001, Henan, Peoples R China

[2] Anhui Normal Univ, Coll Chem & Mat Sci, Wuhu 241000, Anhui, Peoples R China

来源：

APPLIED ORGANOMETALLIC CHEMISTRY | 2018年 / 32卷 / 03期

基金：

中国国家自然科学基金;

关键词：

copper-free conditions; non-phosphorus ligand; Sonogashira reaction; CROSS-COUPLING REACTIONS; MIZOROKI-HECK REACTION; CONJUGATED ENYNES; CARBENE LIGANDS; COMPLEXES; SUZUKI; DERIVATIVES; PALLADACYCLES; ACETYLENES; CHEMISTRY;

D O I：

10.1002/aoc.4156

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Pd(OAc)(2)-catalyzed Sonogashira coupling reactions of alkynes and a variety of aryl halides with 1,3-bis(5-ferrocenylisoxazoline-3-yl)benzene as an efficient non-phosphorus ligand under copper-free conditions are presented. The main advantages over previous methodologies include low catalyst loading (0.2 mol% Pd(OAc)(2) and 0.4 mol% ferrocenyl bisoxazoline ligand are sufficient for these coupling reactions), less problematic reaction medium (water-dimethylformamide) and more convenient operation (no requirement for nitrogen protection).

引用

页数：7

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