Multifunctional poly(aspartic acid) nanoparticles containing iron oxide nanocrystals and doxorubicin for simultaneous cancer diagnosis and therapy

被引：29

作者：

Yang, Hee-Man ^{[1
]}

Oh, Byung Chang ^{[1
]}

Kim, Jong Hun ^{[1
]}

Ahn, Taebin ^{[1
]}

Nam, Ho-Seong ^{[1
]}

Park, Chan Woo ^{[1
]}

Kim, Jong-Duk ^{[1
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn, Grad Program BK21, Taejon 305701, South Korea

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2011年 / 391卷 / 1-3期

关键词：

Poly(aspartic acid)s; Iron oxide nanocrystals; Doxorubicin; Magnetic resonance imaging; Cancer therapy; DRUG-DELIVERY; BREAST-CANCER; MAGNETIC NANOPARTICLES; CARRIER; DERIVATIVES; POLYMER;

D O I：

10.1016/j.colsurfa.2011.04.032

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Multifunctional poly(aspartic acid) nanoparticles for simultaneous cancer diagnosis and therapy were developed. First, iron oxide nanocrystals were loaded in poly(aspartic acid) nanoparticles through an emulsion method using octadecyl grafted poly(aspartic acid). The influence of the organic solvent, used to disperse the hydrophobic iron oxide nanocrystals, on the size and loading efficiency of iron oxide nanocrystals loaded poly(aspartic acid) nanoparticles was investigated. Next, an anticancer drug, doxorubicin (DOX), was incorporated in the magnetic poly(aspartic acid) nanoparticles (MPAN). The presence of iron oxide nanocrystals in the poly(aspartic acid) nanoparticles and their size distribution were confirmed by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), and dynamic light scattering (DLS), respectively. The drug release behavior was also observed for 3 days. From the results of T-2 weighted MR imaging and MTT assays, the DOX loaded MPAN showed high T-2 relaxivity coefficients and high cytotoxicity for cancer cells. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.

引用

页码：208 / 215

页数：8

共 27 条

[1]

Caldwell G, 1997, J APPL POLYM SCI, V66, P911, DOI 10.1002/(SICI)1097-4628(19971031)66:5<911::AID-APP11>3.0.CO

[2]

2-Q

[3] Triblock copolymer coated iron oxide nanoparticle conjugate for tumor integrin targeting [J].

Chen, Kai ;

Xie, Jin ;

Xu, Hengyi ;

Behera, Deepak ;

Michalski, Mark H. ;

Biswal, Sandip ;

Wang, Andrew ;

Chen, Xiaoyuan .

BIOMATERIALS, 2009, 30 (36) :6912-6919

[4]

DROBNIK J, 1989, Advanced Drug Delivery Reviews, V3, P229, DOI 10.1016/0169-409X(89)90012-4

[5] Multifunctional magnetic nanoparticles for medical imaging applications [J].

Fang, Chen ;

Zhang, Miqin .

JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (35) :6258-6266

[6] Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles [J].

Hao, Rui ;

Xing, Ruijun ;

Xu, Zhichuan ;

Hou, Yanglong ;

Gao, Song ;

Sun, Shouheng .

ADVANCED MATERIALS, 2010, 22 (25) :2729-2742

[7] Synthesis and in vitro anti-cancer evaluation of tamoxifen-loaded magnetite/PLLA composite nanoparticles [J].

Hu, F. X. ;

Neoh, K. G. ;

Kang, E. T. .

BIOMATERIALS, 2006, 27 (33) :5725-5733

[8] Iron oxide nanoparticles for sustained delivery of anticancer agents [J].

Jain, Tapan K. ;

Morales, Marco A. ;

Sahoo, Sanjeeb K. ;

Leslie-Pelecky, Diandra L. ;

Labhasetwar, Vinod .

MOLECULAR PHARMACEUTICS, 2005, 2 (03) :194-205

[9] Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats [J].

Jain, Tapan K. ;

Reddy, Maram K. ;

Morales, Marco A. ;

Leslie-Pelecky, Diandra L. ;

Labhasetwar, Vinod .

MOLECULAR PHARMACEUTICS, 2008, 5 (02) :316-327

[10] Effects of grafted alkyl groups on aggregation behavior of amphiphilic poly(aspartic acid) [J].

Kang, HS ;

Yang, SR ;

Kim, JD ;

Han, SH ;

Chang, IS .

LANGMUIR, 2001, 17 (24) :7501-7506

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