Towards synthetic adrenaline receptors - Shape-selective adrenaline recognition in water

被引：0

作者：

Herm, M

Molt, O

Schrader, T ^{[1
]}

机构：

[1] Univ Marburg, Fachbereich Chem, Hans Meerwein Str, D-35032 Marburg, Germany

[2] Dupont Co Inc, Wuppertal, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2001年 / 40卷 / 17期

关键词：

adrenaline; hormones; molecular recognition; receptors; supramolecular chemistry;

D O I：

10.1002/1521-3773(20010903)40:17<3148::AID-ANIE3148>3.0.CO;2-S

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new rationally designed receptor molecule binds adrenaline derivatives in water. Its binding pattern (see picture) imitates the interplay of noncovalent interactions operating in the natural receptor. High shape selectivity is achieved for the slim dopamine skeleton, and leads to rejection of substrates with an a-substituent, such as amino acid derivatives.

引用

页码：3148 / 3151

页数：4

共 22 条

[1] MACROCYCLES CONTAINING TIN - PREPARATION OF MACROBICYCLIC LEWIS ACIDIC HOSTS CONTAINING 2 TIN ATOMS AND SN-119 NMR-STUDIES OF THEIR CHLORIDE AND BROMIDE BINDING-PROPERTIES IN SOLUTION [J].