Recent advances in aptamer-functionalized materials in sample preparation

被引：70

作者：

Du, Fuyou ^{[1
]}

Guo, Lin ^{[1
]}

Qin, Qun ^{[1
]}

Zheng, Xian ^{[1
]}

Ruan, Guihua ^{[1
]}

Li, Jianping ^{[1
]}

Li, Gongke ^{[2
]}

机构：

[1] Guilin Univ Technol, Coll Chem & Bioengn, Guangxi Key Lab Electrochem & Magnetochem Funct M, Guangxi 541004, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2015年 / 67卷

基金：

中国国家自然科学基金;

关键词：

Aptamer; Aptamer-based microfluidics; Aptamer-functionalized material; Complex sample; Enrichment; Purification; Sample preparation; Solid-phase extraction; Solid-phase microextraction; Surface-affinity extraction; SOLID-PHASE MICROEXTRACTION; NUCLEIC-ACID APTAMERS; SWITCHING LIQUID-CHROMATOGRAPHY; MOLECULARLY-IMPRINTED POLYMERS; IONIZATION MASS-SPECTROMETRY; RESTRICTED-ACCESS MATERIAL; CONJUGATED GRAPHENE OXIDE; MULTIPLE CANCER-CELLS; REAL-TIME PCR; AFFINITY-CHROMATOGRAPHY;

D O I：

10.1016/j.trac.2015.01.007

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Aptamer-functionalized materials (AFMs) are promising specific recognition materials in sample-preparation techniques due to the inherently high affinity and selectivity associated with aptamers, so AFMs attract considerable interest and a wide variety of applications to recognize specific target analytes ranging from small molecules to proteins, cells and even tissues. We briefly introduce sample-preparation techniques and potential applications of aptamers in analytical chemistry, and then briefly discuss the preparation of AFMs. We mainly focus on developments and applications of AFMs in sample-preparation techniques, including AF solid-phase extraction, solid-phase microextraction, and microfluidic sample preparation, and other sample-preparation techniques. We also discuss the challenges and the prospects of AFMs in sample preparation in future developments. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：134 / 146

页数：13

共 135 条

[1] SOLID-PHASE MICROEXTRACTION WITH THERMAL-DESORPTION USING FUSED-SILICA OPTICAL FIBERS [J].