Efficacy and safety of intraoperative radiotherapy in colorectal cancer: A systematic review

被引：25
作者：
Cantero-Munoz, P. [1 ]
Urien, M. A. [2 ]
Ruano-Ravina, A. [1 ,3 ,4 ]
机构：
[1] Galician Agcy Hlth Technol Assessment, Galician Dept Hlth, Santiago De Compostela, Spain
[2] Duran & Reynals Hosp, Catalan Inst Oncol ICO, Radiat Oncol Serv, Barcelona, Spain
[3] Univ Santiago de Compostela, Sch Med, Dept Prevent Med & Publ Hlth, Santiago De Compostela 15782, Spain
[4] CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
来源：
CANCER LETTERS | 2011年 / 306卷 / 02期
关键词：
Intraoperative radiotherapy; Colorectal cancer; Systematic review; RECURRENT RECTAL-CANCER; CONTAINING MULTIMODALITY TREATMENT; ELECTRON BOOST RADIOTHERAPY; TOTAL MESORECTAL EXCISION; LOCALLY ADVANCED PRIMARY; RADIATION-THERAPY; IORT; IRRADIATION; COMBINATION; SURGERY;
D O I：
10.1016/j.canlet.2011.02.020
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intraoperative radiotherapy (IORT) has been proposed as an encouraging treatment for colorectal cancer. The aim of this study is to assess the efficacy and safety of IORT for this cancer through a systematic review. Studies located in electronic databases were selected according to established criteria, read and analysed and the results extracted by two independent reviewers. Fifteen studies met the selection criteria. Five-to-six-year local control (LC) was over 80% and 5-year overall survival (OS) was close to 65%. For recurrences, the 5-year overall survival was 30%. The main acute complications were gastrointestinal. Adding IORT to conventional treatment reduces the incidence of local recurrences within the radiation area over 10%. IORT is a safe technique as it does not increase toxicity associated with conventional treatment. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：121 / 133
页数：13
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