Efficacy and safety of intraoperative radiotherapy in colorectal cancer: A systematic review

被引：25
作者：
Cantero-Munoz, P. [1 ]
Urien, M. A. [2 ]
Ruano-Ravina, A. [1 ,3 ,4 ]
机构：
[1] Galician Agcy Hlth Technol Assessment, Galician Dept Hlth, Santiago De Compostela, Spain
[2] Duran & Reynals Hosp, Catalan Inst Oncol ICO, Radiat Oncol Serv, Barcelona, Spain
[3] Univ Santiago de Compostela, Sch Med, Dept Prevent Med & Publ Hlth, Santiago De Compostela 15782, Spain
[4] CIBERESP, CIBER Epidemiol & Salud Publ, Madrid, Spain
来源：
CANCER LETTERS | 2011年 / 306卷 / 02期
关键词：
Intraoperative radiotherapy; Colorectal cancer; Systematic review; RECURRENT RECTAL-CANCER; CONTAINING MULTIMODALITY TREATMENT; ELECTRON BOOST RADIOTHERAPY; TOTAL MESORECTAL EXCISION; LOCALLY ADVANCED PRIMARY; RADIATION-THERAPY; IORT; IRRADIATION; COMBINATION; SURGERY;
D O I：
10.1016/j.canlet.2011.02.020
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intraoperative radiotherapy (IORT) has been proposed as an encouraging treatment for colorectal cancer. The aim of this study is to assess the efficacy and safety of IORT for this cancer through a systematic review. Studies located in electronic databases were selected according to established criteria, read and analysed and the results extracted by two independent reviewers. Fifteen studies met the selection criteria. Five-to-six-year local control (LC) was over 80% and 5-year overall survival (OS) was close to 65%. For recurrences, the 5-year overall survival was 30%. The main acute complications were gastrointestinal. Adding IORT to conventional treatment reduces the incidence of local recurrences within the radiation area over 10%. IORT is a safe technique as it does not increase toxicity associated with conventional treatment. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：121 / 133
页数：13
相关论文
共 31 条
  • [1] *AM CANC SOC, 2009, COL CANC
  • [2] [Anonymous], 2008, WORLD CANC REPORT
  • [3] [Anonymous], 2009, SEER CANC STAT REV 1
  • [4] [Anonymous], 2009, CANC FACTS FIG 2009
  • [5] Intraoperative radiation therapy - Part 2. Clinical results
    Calvo, Felipe A.
    Meirino, Rosa M.
    Orecchia, Roberto
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2006, 59 (02) : 116 - 127
  • [6] Prognostic factors for disease-free survival in patients with T3-4 or N+ rectal cancer treated with preoperative chemoradiation therapy, surgery, and intraoperative irradiation
    Díaz-González, JA
    Calvo, FA
    Cortés, J
    García-Sabrido, JL
    Gómez-Espí, M
    del Valle, E
    Muñoz-Jiménez, F
    Alvarez, E
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 64 (04): : 1122 - 1128
  • [7] Radical resection after IORT-containing multimodality treatment is the most important determinant for outcome in patients treated for locally recurrent rectal cancer
    Dresen, Raphaela C.
    Gosens, Marleen J.
    Martijn, Hendrik
    Nieuwenhuijzen, Grard A.
    Creemers, Geert-Jan
    Daniels-Gooszen, Alette W.
    van den Brule, Adriaan J.
    van den Berg, Hetty A.
    Rutten, Harm J.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2008, 15 (07) : 1937 - 1947
  • [8] Estimates of the cancer incidence and mortality in Europe in 2006
    Ferlay, J.
    Autier, P.
    Boniol, M.
    Heanue, M.
    Colombet, M.
    Boyle, P.
    [J]. ANNALS OF ONCOLOGY, 2007, 18 (03) : 581 - 592
  • [9] Influence of intraoperative and postoperative radiotherapy on functional outcome in patients undergoing standard and deep anterior resection for rectal cancer
    Kienle, Peter
    Abend, Florian
    Dueck, Margret
    Abel, Ulrich
    Treiber, Martina
    Riedl, Stefan
    [J]. DISEASES OF THE COLON & RECTUM, 2006, 49 (05) : 557 - 567
  • [10] Long-term results of intraoperative presacral electron boost radiotherapy (IOERT) in combination with total mesorectal excision (TME) and chemoradiation in patients with locally advanced rectal cancer
    Krempien, Robert
    Roeder, Falk
    Oertel, Susanne
    Roebel, Marianne
    Weitz, Juergen
    Hensley, Frank W.
    Timke, Carmen
    Funk, Angela
    Bischof, Marc
    Zabel-Du Bois, Angelika
    Niethammer, Andreas G.
    Eble, Michael J.
    Buchler, Markus W.
    Treiber, Martina
    Debus, Juergen
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2006, 66 (04): : 1143 - 1151
1234