Effect on metabolic bone disease markers in the neonatal intensive care unit with implementation of a practice guideline

被引：3

作者：

Sabroske, Elizabeth Marie ^{[1
]}

Payne, Davis Harrison ^{[2
]}

Stine, Christina Nicole ^{[3
]}

Kathen, Charmaine Marie ^{[4
]}

Sollohub, Heather Marie ^{[4
]}

Kohlleppel, Katy Leanne ^{[4
]}

Lorbieski, Pamela Louise ^{[4
]}

Carney, Jennifer Elizabeth ^{[4
]}

Motta, Cheryl Leah ^{[1
,4
]}

Pierce, Maria Rodriguez ^{[1
,4
]}

Ahmad, Kaashif Aqeeb ^{[1
,4
,5
]}

机构：

[1] Baylor Coll Med, San Antonio, TX 78207 USA

[2] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[3] Cent Ohio Newborn Med, Columbus, OH USA

[4] Pediat Med Grp San Antonio, San Antonio, TX 78229 USA

[5] MEDNAX Natl Med Grp, Ctr Res Educ Qual & Safety, Sunrise, FL 33323 USA

来源：

JOURNAL OF PERINATOLOGY | 2020年 / 40卷 / 08期

关键词：

SERUM ALKALINE-PHOSPHATASE; BIRTH-WEIGHT INFANTS; REQUIREMENTS; OSTEOPENIA;

D O I：

10.1038/s41372-020-0693-2

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objectives To determine the effect of implementing a 2015 policy for the screening, prevention, and management of metabolic bone disease for very low birth weight (VLBW) infants in two Level IV NICUs. Study design Retrospective cohort study of VLBW infants in the 2 years prior to (2013-2014) and after (2016-2017) policy implementation. Results We identified 316 VLBW infants in 2013-2014 and 292 in 2016-2017 who met study criteria. After policy implementation, vitamin D supplementation began earlier (20.1 +/- 15.5 days vs 30.2 +/- 20.1 days, p < 0.0005), the percentage of infants with alkaline phosphatase obtained increased (89.7% vs 76.3%, p < 0.0005), while the percentage of infants with alkaline phosphatase >800 IU/L (11.7 vs 4.5%, p = 0.0001) and phosphorous <4 mg/dL (14.2% vs 7.9%, p = 0.014) fell significantly. Conclusions After policy implementation, vitamin D supplementation began significantly earlier and the rate of detecting abnormal biochemical markers of metabolic bone disease decreased significantly.

引用

页码：1267 / 1272

页数：6

共 14 条

[1] Serial serum alkaline phosphatase as an early biomarker for osteopenia of prematurity [J].