Does It MEK a Difference? Understanding Immune Effects of Targeted Therapy

被引：21

作者：

Cooper, Zachary A. ^{[1
,2
]}

Reuben, Alexandre ^{[1
]}

Austin-Breneman, Jacob ^{[1
]}

Wargo, Jennifer A. ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Genom Med, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2015年 / 21卷 / 14期

关键词：

BRAF INHIBITION; T-CELLS; MELANOMA; TUMOR; COMBINATION;

D O I：

10.1158/1078-0432.CCR-15-0363

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BRAF inhibitor (BRAFi) treatment enhances antitumor immunity, but is associated with increased intratumoral PD-L1 expression. MEK inhibitors (MEKi) may alter T-cell function; however, recent studies demonstrate preserved T-cell infiltrate during treatment with BRAFi/MEKi. These data have important implications for combining BRAFi/MEKi and checkpoint blockade in the treatment of melanoma. (C) 2015 AACR.

引用

页码：3102 / 3104

页数：3

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