Turning Cold into Hot: Firing up the Tumor Microenvironment

被引：666

作者：

Duan, Qianqian ^{[1
,2
]}

Zhang, Hualing ^{[3
]}

Zheng, Junnian ^{[4
]}

Zhang, Lianjun ^{[1
,2
]}

机构：

[1] Suzhou Inst Syst Med, Suzhou 215123, Jiangsu, Peoples R China

[2] Chinese Acad Med Sci & Peking Union Med Coll, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China

[3] Qingdao Univ, Affiliated Hosp, Dept Gynecol, Qingdao, Peoples R China

[4] Xuzhou Med Univ, Inst Canc, Jiangsu Ctr Collaborat & Innovat Canc Biotherapy, Xuzhou 221002, Jiangsu, Peoples R China

来源：

TRENDS IN CANCER | 2020年 / 6卷 / 07期

基金：

国家重点研发计划;

关键词：

T-CELLS; CHROMATIN ACCESSIBILITY; DENDRITIC CELLS; ANTITUMOR IMMUNITY; CANCER; LANDSCAPE; INFLAMMATION; METABOLISM; CONTEXTURE; REPROGRAMS;

D O I：

10.1016/j.trecan.2020.02.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancers develop within complex tissue environments consisting of diverse innate and adaptive immune cells, along with stromal cells, vascular networks, and many other cellular and noncellular components. The high heterogeneity within the tumor microenvironment (TME) remains a key obstacle in understanding and treating cancer. Understanding the dynamic functional interplay within this intricate ecosystem will provide important insights into the design of effective combinatorial strategies against cancer. Here, we present recent technical advances to explore the complexity of the TME. Then, we discuss how innate immune sensing machinery, genetic alterations of oncogenic signaling, cellular metabolism, and epigenetic factors are involved in modulating the TME. Finally, we summarize the potential strategies to boost antitumor immunity by therapeutically exploiting the TME.

引用

页码：605 / 618

页数：14

共 104 条

[1] Lighting a Fire in the Tumor Microenvironment Using Oncolytic Immunotherapy [J].

Achard, Carole ;

Surendran, Abera ;

Wedge, Marie-Eve ;

Ungerechts, Guy ;

Bell, John ;

Ilkow, Carolina S. .

EBIOMEDICINE, 2018, 31 :17-24

[2] TOX reinforces the phenotype and longevity of exhausted T cells in chronic viral infection [J].

Alfei, Francesca ;

Kanev, Kristiyan ;

Hofmann, Maike ;

Wu, Ming ;

Ghoneim, Hazem E. ;

Roelli, Patrick ;

Utzschneider, Daniel T. ;

von Hoesslin, Madlaina ;

Cullen, Jolie G. ;

Fan, Yiping ;

Eisenberg, Vasyl ;

Wohlleber, Dirk ;

Steiger, Katja ;

Merkler, Doron ;

Delorenzi, Mauro ;

Knolle, Percy A. ;

Cohen, Cyrille J. ;

Thimme, Robert ;

Youngblood, Benjamin ;

Zehn, Dietmar .

NATURE, 2019, 571 (7764) :265-+

[3] Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment [J].

Azizi, Elham ;

Carr, Ambrose J. ;

Plitas, George ;

Cornish, Andrew E. ;

Konopacki, Catherine ;

Prabhakaran, Sandhya ;

Nainys, Juozas ;

Wu, Kenmin ;

Kiseliovas, Vaidotas ;

Setty, Manu ;

Choi, Kristy ;

Fromme, Rachel M. ;

Phuong Dao ;

McKenney, Peter T. ;

Wasti, Ruby C. ;

Kadaveru, Krishna ;

Mazutis, Linas ;

Rudensky, Alexander Y. ;

Pe'er, Dana .

CELL, 2018, 174 (05) :1293-+

[4] Inflammation and cancer: back to Virchow? [J].

Balkwill, F ;

Mantovani, A .

LANCET, 2001, 357 (9255) :539-545

[5] Intratumoral IL-12 combined with CTLA-4 blockade elicits T cell-mediated glioma rejection [J].

Berg, Johannes vom ;

Vrohlings, Melissa ;

Haller, Sergio ;

Haimovici, Aladin ;

Kulig, Paulina ;

Sledzinska, Anna ;

Weller, Michael ;

Becher, Burkhard .

JOURNAL OF EXPERIMENTAL MEDICINE, 2013, 210 (13) :2803-2811

[6] Spatiotemporal Dynamics of Intratumoral Immune Cells Reveal the Immune Landscape in Human Cancer [J].

Bindea, Gabriela ;

Mlecnik, Bernhard ;

Tosolini, Marie ;

Kirilovsky, Amos ;

Waldner, Maximilian ;

Obenauf, Anna C. ;

Angell, Helen ;

Fredriksen, Tessa ;

Lafontaine, Lucie ;

Berger, Anne ;

Bruneval, Patrick ;

Fridman, Wolf Herman ;

Becker, Christoph ;

Pages, Franck ;

Speicher, Michael R. ;

Trajanoski, Zlatko ;

Galon, Jerome .

IMMUNITY, 2013, 39 (04) :782-795

[7] Understanding the tumor immune microenvironment (TIME) for effective therapy [J].

Binnewies, Mikhail ;

Roberts, Edward W. ;

Kersten, Kelly ;

Chan, Vincent ;

Fearon, Douglas F. ;

Merad, Miriam ;

Coussens, Lisa M. ;

Gabrilovich, Dmitry I. ;

Ostrand-Rosenberg, Suzanne ;

Hedrick, Catherine C. ;

Vonderheide, Robert H. ;

Pittet, Mikael J. ;

Jain, Rakesh K. ;

Zou, Weiping ;

Howcroft, T. Kevin ;

Woodhouse, Elisa C. ;

Weinberg, Robert A. ;

Krummel, Matthew F. .

NATURE MEDICINE, 2018, 24 (05) :541-550

[8] Combination of Synthetic Long Peptides and XCL1 Fusion Proteins Results in Superior Tumor Control [J].

Botelho, Natalia K. ;

Tschumi, Benjamin O. ;

Hubbell, Jeffrey A. ;

Swartz, Melody A. ;

Donda, Alena ;

Romero, Pedro .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[9] Single-cell chromatin accessibility reveals principles of regulatory variation [J].

Buenostro, Jason D. ;

Wu, Beijing ;

Litzenburger, Ulrike M. ;

Ruff, Dave ;

Gonzales, Michael L. ;

Snyder, Michael P. ;

Chang, Howard Y. ;

Greenleaf, William J. .

NATURE, 2015, 523 (7561) :486-U264

[10] Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer [J].

Cao, Wei ;

Ramakrishnan, Rupal ;

Tuyrin, Vladimir A. ;

Veglia, Filippo ;

Condamine, Thomas ;

Amoscato, Andrew ;

Mohammadyani, Dariush ;

Johnson, Joseph J. ;

Zhang, Lan Min ;

Klein-Seetharaman, Judith ;

Celis, Esteban ;

Kagan, Valerian E. ;

Gabrilovich, Dmitry I. .

JOURNAL OF IMMUNOLOGY, 2014, 192 (06) :2920-2931

← 1 2 3 4 5 6 7 8 9 10 →