Immunology in the Clinic Review Series; focus on host responses: T cell responses to herpes simplex viruses

被引：29

作者：

Laing, K. J. ^{[1
]}

Dong, L. ^{[1
]}

Sidney, J. ^{[6
]}

Sette, A. ^{[6
]}

Koelle, D. M. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Washington, Dept Med, Seattle, WA 98195 USA

[2] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

[3] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, Benaroya Res Inst, Seattle, WA 98104 USA

[5] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98104 USA

[6] Ctr Infect Dis, La Jolla Inst Allergy & Immunol, La Jolla, CA USA

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 167卷 / 01期

关键词：

antigen; epitope; herpes simplex virus; lymphocyte; vaccine; TYPE-2 TEGUMENT PROTEINS; PLACEBO-CONTROLLED TRIAL; GLYCOPROTEIN-K GK; GENITAL HERPES; HSV-1; REACTIVATION; IFN-GAMMA; IN-VIVO; LYMPHOCYTE CYTOTOXICITY; HAPLOTYPE FREQUENCIES; AMERICAN POPULATION;

D O I：

10.1111/j.1365-2249.2011.04502.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Herpes virus infections are chronic and co-exist with acquired immune responses that generally prevent severe damage to the host, while allowing periodic shedding of virus and maintenance of its transmission in the community. Herpes simplex viruses type 1 and 2 (HSV-1, HSV-2) are typical in this regard and are representative of the viral subfamily Alphaherpesvirinae, which has a tropism for neuronal and epithelial cells. This review will emphasize recent progress in decoding the physiologically important CD8+ and CD4+ T cell responses to HSV in humans. The expanding data set is discussed in the context of the search for an effective HSV vaccine as therapy for existing infections and to prevent new infections.

引用

页码：47 / 58

页数：12

共 97 条

[1]

Arvin A, 2007, HUMAN HERPESVIRUSES: BIOLOGY, THERAPY, AND IMMUNOPROPHYLAXIS, P700

[2] The antiapoptotic herpes simplex virus glycoprotein J localizes to multiple cellular organelles and induces reactive oxygen species formation [J].