High-throughput photocapture approach for reaction discovery

被引：50

作者：

Bayly, Alison A. ^{[1
]}

McDonald, Benjamin R. ^{[1
]}

Mrksich, Milan ^{[1
]}

Scheidt, Karl A. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2020年 / 117卷 / 24期

关键词：

high-throughput analysis; self-assembled monolayers; photocapture; azoliums; MASS-SPECTROMETRY; PHOTOREDOX CATALYSIS; RADICAL REACTIONS; LIGHT; OXIDATION; ALDEHYDES;

D O I：

10.1073/pnas.2003347117

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Modern organic reaction discovery and development relies on the rapid assessment of large arrays of hypothesis-driven experiments. The time-intensive nature of reaction analysis presents the greatest practical barrier for the execution of this iterative process that underpins the development of new bioactive agents. Toward addressing this critical bottleneck, we report herein a high-throughput analysis (HTA) method of reaction mixtures by photocapture on a 384-spot diazirine-terminated self-assembled monolayer, and self-assembled monolayers for matrix-assisted laser desorption/ionization mass spectrometry (SAMDI-MS) analysis. This analytical platform has been applied to the identification of a single-electron-promoted reductive coupling of acyl azolium species.

引用

页码：13261 / 13266

页数：6

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