Synthesis and Radioluminescence of PEGylated Eu3+-doped Nanophosphors as Bioimaging Probes

被引:122
作者
Sun, Conroy [1 ,2 ]
Pratx, Guillem [1 ,2 ]
Carpenter, Colin M. [1 ,2 ]
Liu, Hongguang [1 ,3 ]
Cheng, Zhen [1 ,3 ]
Gambhir, Sanjiv Sam [1 ,3 ]
Xing, Lei [1 ,2 ]
机构
[1] Stanford Univ, Mol Imaging Program Stanford, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Radiat Oncol, Stanford, CA 94305 USA
[3] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
INFRARED UP-CONVERSION; THERMAL-DECOMPOSITION; NANOCRYSTALS; LUMINESCENCE; YB3+; LIGHT; TM3+;
D O I
10.1002/adma.201100919
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Lanthanide-doped nanophosphors stimulated by high-energy photons or beta(+)-particles display characteristic 590, 615, and 692 nm emissions of the Eu3+ activator. These radioluminescent nanophosphors, produced by a thermo degradation process and coated with poly(ethylene glycol), serve as imaging probes as demonstrated in vivo with matrigel inclusions detected by both a custom X-ray luminescence and a conventional small animal optical imaging system.
引用
收藏
页码:H195 / H199
页数:5
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