Role of medullary excitatory amino acid receptors in mediating the 10-Hz rhythm in sympathetic nerve discharge of cats

被引：12

作者：

Barman, SM ^{[1
]}

Orer, HS

Gebber, GL

机构：

[1] Michigan State Univ, Dept Pharmacol & Toxicol, E Lansing, MI 48824 USA

[2] Hacettepe Univ, Fac Med, Dept Pharmacol, TR-06100 Ankara, Turkey

来源：

BRAIN RESEARCH | 2005年 / 1049卷 / 02期

关键词：

caudal ventrolateral medulla; lateral tegmental field; NMDA and non-NMDA receptors; rhythm generation; rostral ventrolateral medulla;

D O I：

10.1016/j.brainres.2005.05.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We tested the hypothesis that excitatory amino acid (EAA)-mediated transmission plays a role in generating the 10-Hz rhythm in sympathetic nerve discharge (SND) of baroreceptor-denervated, urethane-anesthetized cats. Microinjection of either an N-methyl-D-aspartate (NMDA) or non-NMDA receptor antagonist into any one of three medullary regions (lateral tegmental field, rostra], or caudal ventrolateral medulla) essentially eliminated the 10-Hz rhythm in inferior cardiac SND. We conclude that EAA receptors in the medulla are critical for generation of the 10-Hz rhythm. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：249 / 253

页数：5

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