Endothelin in Nondiabetic Chronic Kidney Disease: Preclinical and Clinical Studies

被引：14
作者：
Culshaw, Geoff J. [1 ]
MacIntyre, Iain M. [1 ]
Dhaun, Neeraj [1 ]
Webb, David J. [1 ]
机构：
[1] Univ Edinburgh, Univ British Heart Fdn, Ctr Cardiovasc Sci, Queens Med Res Inst, Edinburgh EH16 4TJ, Midlothian, Scotland
来源：
SEMINARS IN NEPHROLOGY | 2015年 / 35卷 / 02期
关键词：
Chronic kidney disease; endothelin; endothelin-receptor antagonist; proteinuria; blood pressure; A RECEPTOR ANTAGONISM; DUCT-SPECIFIC KNOCKOUT; NOCTURNAL BLOOD-PRESSURE; ANGIOTENSIN-II; CARDIOVASCULAR-DISEASE; ARTERIAL STIFFNESS; CONVERTING ENZYME; PODOCYTE INJURY; RENAL-DISEASE; VASA-RECTA;
D O I：
10.1016/j.semnephrol.2015.03.002
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The incidence and prevalence of chronic kidney disease (CKD) is increasing. Despite current therapies, many patients with CKD have suboptimal blood pressure, ongoing proteinuria, and develop progressive renal dysfunction. Further therapeutic options therefore are required. Over the past 20 years the endothelin (ET) system has become a prime target. Experimental models have shown that ET-1, acting primarily via the endothelin-A receptor, plays an important role in the development of proteinuria, glomerular injury, fibrosis, and inflammation. Subsequent animal and early clinical studies using ET-receptor antagonists have suggested that theses therapies may slow renal disease progression primarily through blood pressure and proteinuria reduction. This review examines the current literature regarding the ET system in nondiabetic CKD. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：176 / 187
页数：12
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