Conformational and segmental dynamics in lipid-based vesicles

被引：26

作者：

Gerelli, Yuri ^{[1
,2
,4
]}

Sakai, Victoria Garcia ^{[3
]}

Ollivier, Jacques ^{[4
]}

Deriu, Antonio ^{[1
,2
]}

机构：

[1] Univ Parma, Dipartimento Fis, I-43124 Parma, Italy

[2] CNISM, I-43124 Parma, Italy

[3] Rutherford Appleton Lab, ISIS Facil, Didcot OX11 OQX, Oxon, England

[4] Inst Max Von Laue Paul Langevin, F-38042 Grenoble 9, France

来源：

SOFT MATTER | 2011年 / 7卷 / 08期

关键词：

ELASTIC NEUTRON-SCATTERING; MOLECULAR-DYNAMICS; PHOSPHOLIPID-BILAYERS; DRUG-DELIVERY; NANOPARTICLES; MEMBRANES; RELAXATION; LIPOSOMES; CHITOSAN; SIMULATION;

D O I：

10.1039/c0sm01301c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We have performed a detailed analysis of the conformational and segmental dynamics in lipid-based vesicles using quasielastic neutron scattering. Our data evidence the presence of dynamical heterogeneities: the hydrogens in the headgroups and in the initial part of the hydrophobic chains perform slow diffusive motions in a confined volume; those belonging to the end part of the chains show a faster confined diffusivity together with torsional isomerization transitions. A model with three hydrogen populations has been proposed to describe the main features of this complex dynamics. The addition of a charged polysaccharide component to the vesicles mostly slows the dynamics of the headgroups and of the upper part of the acyl chains without significantly affecting the isomerization dynamics.

引用

页码：3929 / 3935

页数：7

共 44 条

[1]

Bee M., 1998, Quasielastic Neutron Scattering: Principles and Applications in Solid State Chemistry, Biology and Materials Science, P28

[2] STRUCTURAL DYNAMICS IN PHOSPHOLIPID-BILAYERS FROM DEUTERIUM SPIN-LATTICE RELAXATION-TIME MEASUREMENTS [J].

BROWN, MF ;

SEELIG, J ;

HABERLEN, U .

JOURNAL OF CHEMICAL PHYSICS, 1979, 70 (11) :5045-5053

[3] ALKYL CHAIN MOTIONS IN COLUMNAR MESOPHASES - A QUASI-ELASTIC NEUTRON-SCATTERING STUDY OF DICOPPER TETRAPALMITATE [J].

CARPENTIER, L ;

BEE, M ;

GIROUDGODQUIN, AM ;

MALDIVI, P ;

MARCHON, JC .

MOLECULAR PHYSICS, 1989, 68 (06) :1367-1378

[4] FACTORS AFFECTING THE STABILITY OF DRY LIPOSOMES [J].

CROWE, JH ;

CROWE, LM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 939 (02) :327-334

[5] Nanoparticle therapeutics: an emerging treatment modality for cancer [J].

Davis, Mark E. ;

Chen, Zhuo ;

Shin, Dong M. .

NATURE REVIEWS DRUG DISCOVERY, 2008, 7 (09) :771-782

[6] The dynamical transition of proteins, concepts and misconceptions [J].

Doster, Wolfgang .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2008, 37 (05) :591-602

[7] A molecular view of melting in anhydrous phospholipidic membranes [J].

Doxastakis, M. ;

Sakai, V. Garcia ;

Ohtake, S. ;

Maranas, J. K. ;

de Pablo, J. J. .

BIOPHYSICAL JOURNAL, 2007, 92 (01) :147-161

[8] Dynamical properties of phospholipid bilayers from computer simulation [J].

Essmann, U ;

Berkowitz, ML .

BIOPHYSICAL JOURNAL, 1999, 76 (04) :2081-2089

[9] Internal molecular motions of bacteriorhodopsin: Hydration-induced flexibility studied by quasielastic incoherent neutron scattering using oriented purple membranes [J].

Fitter, J ;

Lechner, RE ;

Buldt, G ;

Dencher, NA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7600-7605

[10] Hydration-dependent internal dynamics of reverse micelles: A quasielastic neutron scattering study [J].

Freda, M ;

Onori, G ;

Paciaroni, A ;

Santucci, A .

PHYSICAL REVIEW E, 2003, 68 (02) :7

← 1 2 3 4 5 →