Hydroxyquinoline based binders: Promising ligands for chelatotherapy?

被引：65

作者：

Budimir, Ana ^{[1
,2
]}

Humbert, Nicholas ^{[2
]}

Elhabiri, Mourad ^{[2
]}

Osinska, Iwona ^{[2
]}

Birus, Mladen ^{[1
]}

Albrecht-Gary, Anne-Marie ^{[2
]}

机构：

[1] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia

[2] Univ Strasbourg, CNRS, UMR 7177, Lab Physicochim Bioinorgan, Strasbourg, France

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2011年 / 105卷 / 03期

关键词：

Clioquinol; Alzheimer's disease; Metal ions; Stability constants; MULTIWAVELENGTH SPECTROSCOPIC DATA; METAL CHELATION-THERAPY; TARGETING A-BETA; ALZHEIMERS-DISEASE; AMYLOID-BETA; EQUILIBRIUM-CONSTANTS; STABILITY-CONSTANTS; ZINC-BINDING; CLIOQUINOL; PEPTIDE;

D O I：

10.1016/j.jinorgbio.2010.08.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here a thorough physico-chemical study of the coordination properties of clioquinol, an oxine-type active neurological drug in Alzheimer's disease, toward biologically relevant divalent metal ions (Cu, Zn, Ni, Co and Mn). Using a fruitful combination of electrospray mass spectrometry, absorption spectrophotometry and potentiometry, we have characterized the mono- and bis-chelated metal ion species. The determination of the stability constants showed a classical thermodynamic behavior along the studied series with the cupric complexes being by far the most stable species. Our data are discussed within the scope of Alzheimer's disease. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：490 / 496

页数：7

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