Acetogenic isoquinoline alkaloids.: Part 113 -: The polyketide folding mode in the biogenesis of isoshinanolone and plumbagin from Ancistrocladus heyneanus (Ancistrocladaceae)

被引：33

作者：

Bringmann, G ^{[1
]}

Wohlfarth, M ^{[1
]}

Rischer, H ^{[1
]}

Ruckert, M ^{[1
]}

Schlauer, J ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Organ Chem, D-97074 Wurzburg, Germany

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 46期

关键词：

D O I：

10.1016/S0040-4039(98)01935-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biosynthetic origins of the tetralone isoshinanolone and the related naphthoquinone plumbagin were investigated by feeding [C-13(2)]-acetate to suspended callus cultures of Ancistrocladus heyneanus. The orientation of the acetate subunits was elucidated by a similar experiment using [2-C-13]-acetate. The polyketide folding mode found for isoshinanolone and plumbagin constitutes a further hint at the acetogenic nature of the naphthylisoquinoline alkaloids, which are typical of A. heyneanus and other species of Ancistrocladaceae and Dioncophyllaceae. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8445 / 8448

页数：4

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