Protein SUMOylation modification and its associations with disease

被引：165

作者：

Yang, Yanfang ^{[1
,2
,3
]}

He, Yu ^{[1
,2
,3
]}

Wang, Xixi ^{[1
,2
,3
]}

Liang, Ziwei ^{[1
,2
,3
]}

He, Gu ^{[1
,2
,3
]}

Zhang, Peng ^{[4
]}

Zhu, Hongxia ^{[5
,6
,7
]}

Xu, Ningzhi ^{[1
,2
,3
,5
,6
,7
]}

Liang, Shufang ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Sichuan, Peoples R China

[3] Collaborat Innovat Ctr Biotherapy, 17,3rd Sect Peoples South Rd, Chengdu 610041, Sichuan, Peoples R China

[4] Sichuan Univ, West China Hosp, Dept Urinary Surg, Chengdu 610041, Sichuan, Peoples R China

[5] Chinese Acad Med Sci, Lab Cell & Mol Biol, Beijing 100034, Peoples R China

[6] Chinese Acad Med Sci, State Key Lab Mol Oncol, Canc Inst, Beijing 100034, Peoples R China

[7] Chinese Acad Med Sci, Canc Hosp, Beijing 100034, Peoples R China

来源：

OPEN BIOLOGY | 2017年 / 7卷 / 10期

基金：

中国国家自然科学基金;

关键词：

SUMOylation; SUMO pathway; deSUMOylation; disease; A-BETA GENERATION; SUMO MODIFICATION; POSTTRANSLATIONAL MODIFICATIONS; HEPATOCELLULAR-CARCINOMA; ALZHEIMERS-DISEASE; CONJUGATING ENZYME; MASS-SPECTROMETRY; ANALYSIS REVEALS; UBIQUITIN; IDENTIFICATION;

D O I：

10.1098/rsob.170167

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis. The imbalance of SUMOylation and deSUMOylation has been associated with the occurrence and progression of various diseases. Herein, we summarize and discuss the signal crosstalk between SUMOylation and ubiquitination of proteins, protein SUMOylation relations with several diseases, and the identification approaches for SUMOylation site. With the continuous development of bioinformatics and mass spectrometry, several accurate and high-throughput methods have been implemented to explore small ubiquitin-likemodifier-modified substrates and sites, which is helpful for deciphering protein SUMOylation-mediated molecular mechanisms of disease.

引用

页数：10

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