Hypofractionated radiotherapy for non-metastatic bone and soft tissue sarcomas

被引:4
作者
Sari, S. Yuce [1 ]
Cengiz, M. [1 ]
Dauletkazin, A. [2 ]
Yazici, G. [1 ]
Gultekin, M. [1 ]
Hurmuz, P. [1 ]
Yildiz, F. [1 ]
Zorlu, F. [1 ]
Gurkaynak, M. [1 ]
Akyol, F. [1 ]
Ozyigit, G. [1 ]
机构
[1] Hacettepe Univ, Dept Radiat Oncol, Med Sch, TR-06100 Ankara, Turkey
[2] Mehmet Akif Inan Training & Res Hosp, Dept Radiat Oncol, Sanliurfa, Turkey
来源
CANCER RADIOTHERAPIE | 2019年 / 23卷 / 08期
关键词
Sarcoma; Radiotherapy; Hypofractionation; Stereotactic body radiotherapy; RADIATION-THERAPY; PROGNOSTIC-FACTORS; STEREOTACTIC RADIOSURGERY; POSTOPERATIVE RADIOTHERAPY; RETROPERITONEAL SARCOMAS; PREOPERATIVE RADIATION; DOSE-ESCALATION; MANAGEMENT; EXTREMITY; HEAD;
D O I
10.1016/j.canrad.2019.06.011
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose. - To evaluate the efficacy and toxicity of hypofractionated radiotherapy in non-metastatic soft tissue and bone sarcomas. Patients and methods. - Thirty patients underwent hypofractionated radiotherapy between 2007 and 2015. Overall, 17 patients underwent primary hypofractionated radiotherapy, nine underwent hypofractionated radiotherapy for reirradiation, and four received a boost dose via hypofractionated radiotherapy after external beam radiotherapy. Most common disease sites were head and neck and retroperitoneum. Hypofractionated radiotherapy was administered with a definitive, adjuvant, or neoadjuvant intent. Results. - Median age was 37 years (range: 11-82 years). Median hypofractionated radiotherapy dose was 35 Gy (range: 20-50 Gy) in three to five fractions. Median follow-up was 21 months (range: 1-108 months). One- and 2-year overall survival rate was 75% and 52%, respectively. One- and 2-year local recurrence-free survival rate was 59% and 48%, with local recurrence rates of 16% and 33% in 1 and 2 years, respectively. Univariate analysis revealed tumour size (P= 0.04), hypofractionated radiotherapy intent (P= 0.016) and reirradiation (P= 0.001) as prognostic factors for local recurrence-free survival. Severe late toxicity was observed in one patient as grade 3 trismus. Conclusion. - Hypofractionated radiotherapy as the primary treatment or for reirradiation has been shown to be safe in the treatment of bone and soft tissue sarcomas. It can provide relatively good local control and survival rates. (C) 2019 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:853 / 859
页数:7
相关论文
共 50 条
  • [21] Advances in Radiation Therapy for Primary and Metastatic Adult Soft Tissue Sarcomas
    Blumenfeld, Philip
    Sen, Neilayan
    Abrams, Ross
    Wang, Dian
    CURRENT ONCOLOGY REPORTS, 2016, 18 (06)
  • [22] Preoperative hypofractionated radiotherapy for soft tissue sarcoma
    Roeder, Falk
    LANCET ONCOLOGY, 2022, 23 (12) : 1481 - 1482
  • [23] Radiotherapy for soft tissue sarcomas
    Domschikowski, J.
    Dunst, J.
    ONKOLOGIE, 2023, 29 (02): : 105 - 110
  • [24] Outcomes and toxicity of radiotherapy for refractory bone and soft tissue sarcomas
    Doi, Hiroshi
    Oh, Ryoong-Jin
    Miura, Hideharu
    Masai, Norihisa
    Shiomi, Hiroya
    Inoue, Toshihiko
    MOLECULAR AND CLINICAL ONCOLOGY, 2016, 4 (01) : 83 - 88
  • [25] Outcome and Toxicity of Carbon Ion Radiotherapy for Axial Bone and Soft Tissue Sarcomas
    Cuccia, Francesco
    Fiore, Maria Rosaria
    Barcellini, Amelia
    Iannalfi, Alberto
    Vischioni, Barbara
    Ronchi, Sara
    Bonora, Maria
    Riva, Giulia
    Vai, Alessandro
    Facoetti, Angelica
    Preda, Lorenzo
    Valvo, Francesca
    Vitolo, Viviana
    ANTICANCER RESEARCH, 2020, 40 (05) : 2853 - 2859
  • [26] Non-metastatic unresected paediatric non-rhabdomyosarcoma soft tissue sarcomas: Results of a pooled analysis from United States and European groups
    Ferrari, Andrea
    Miceli, Rosalba
    Rey, Annie
    Oberlin, Odile
    Orbach, Daniel
    Brennan, Bernadette
    Mariani, Luigi
    Carli, Modesto
    Bisogno, Gianni
    Cecchetto, Giovanni
    De Salvo, Gian Luca
    Casanova, Michela
    Vannoesel, Max M.
    Kelsey, Anna
    Stevens, Michael C.
    Devidas, Meenakshi
    Pappo, Alberto S.
    Spunt, Sheri L.
    EUROPEAN JOURNAL OF CANCER, 2011, 47 (05) : 724 - 731
  • [27] Grading of soft tissue and bone sarcomas
    Petersen, I.
    Wardelmann, E.
    PATHOLOGE, 2016, 37 (04): : 320 - 327
  • [28] Multimodal Therapy of primary, non-metastatic retroperitoneal Sarcomas
    Ptok, Henry
    Schalk, Enrico
    Hass, Peter
    Heinze, Constanze
    Brunner, Thomas
    Croner, Roland S.
    ZENTRALBLATT FUR CHIRURGIE, 2020, 145 (05): : 405 - 416
  • [29] TREATMENT OF EXTREMITY SOFT-TISSUE SARCOMAS WITH SURGERY AND RADIOTHERAPY
    ROBINSON, M
    BARR, L
    FISHER, C
    FRYATT, I
    STOTTER, A
    HARMER, C
    WILTSHAW, E
    WESTBURY, G
    RADIOTHERAPY AND ONCOLOGY, 1990, 18 (03) : 221 - 233
  • [30] Soft-tissue sarcomas
    Vodanovich, Domagoj Ante
    Choong, Peter F. M.
    INDIAN JOURNAL OF ORTHOPAEDICS, 2018, 52 (01) : 35 - 44