Preparation of magnetite aqueous dispersion for magnetic fluid hyperthermia

被引：31

作者：

Kikuchi, Teppei ^{[4
]}

Kasuya, Ryo ^{[4
]}

Endo, Shota ^{[3
]}

Nakamura, Akira ^{[3
]}

Takai, Toshiyuki ^{[3
]}

Metzler-Nolte, Nils ^{[2
]}

Tohji, Kazuyuki ^{[4
]}

Balachandran, Jeyadevan ^{[1
]}

机构：

[1] Univ Shifa Prefecture, Sch Engn, Dept Mat Sci, Hikone City, Shiga 5228533, Japan

[2] Ruhr Univ Bochum, Fac Chem & Biochem, D-44801 Bochum, Germany

[3] Tohoku Univ, Inst Dev Aging & Canc, Aoba Ku, Sendai, Miyagi 9808575, Japan

[4] Tohoku Univ, Grad Sch Environm Sci, Aoba Ku, Sendai, Miyagi 9808579, Japan

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2011年 / 323卷 / 10期

关键词：

Magnetic fluid hyperthermia; Surface modification; Thermal decomposition; IRON-OXIDE NANOCRYSTALS; THERMAL-DECOMPOSITION; NANOPARTICLES; MECHANISM;

D O I：

10.1016/j.jmmm.2010.11.009

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

An aqueous magnetic suspension was prepared by dispersing amphiphilic co-polymer-coated mono-dispersed magnetite nanoparticles synthesized through thermal decomposition of iron acetylacetonate (Fe(acac)(3)) in a mixture of oleic acid and oleylamine. The average diameter of narrow-size-distributed magnetite nanoparticles varied between 5 and 12 nm depending on the experimental parameters such as reaction temperature, metal salt concentration and oleic acid/oleylamine ratio. Though the as-synthesized particles were coated with oleate and were dispersible in organic solvent, their surfaces were modified using amphiphilic co-polymers composed of poly(maleic anhydride-alt-1-octadecene) and polyethylene glycol-methyl ether and made dispersible in water. Infrared spectra of the sample indicated the existence of -COOH groups on the surface for further conjugation with biomolecules for targeted cancer therapy. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：1216 / 1222

页数：7

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