Cytochrome c oxidase deficient cells accumulate in the hippocampus and choroid plexus with age

被引：97

作者：

Cottrell, DA ^{[1
]}

Blakely, EL

Johnson, MA

Ince, PG

Borthwick, GM

Turnbull, DM

机构：

[1] Newcastle Univ, Sch Med, Dept Neurol, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Newcastle Univ, Newcastle Gen Hosp, MRC, Dev Ctr Clin Brain Aging, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England

来源：

NEUROBIOLOGY OF AGING | 2001年 / 22卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

aging; choroid plexus; cytochrome c oxidase; deficient; neurons; succinate dehydrogenase;

D O I：

10.1016/S0197-4580(00)00234-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The chronological accumulation of mitochondrial dysfunction has been proposed as a potential mechanism in the physiological processes of aging. Cytochrome c oxidase deficient, succinate dehydrogenase positive muscle fibers containing high copy numbers of a mitochondrial DNA mutation are a pathological hallmark of mitochondrial DNA disorders. We show that there is an age-related increase in cytochrome c oxidase-deficient cells in both hippocampal pyramidal neurons and choroid plexus epithelial cells. We suggest that these cells contribute to the cell death and dysfunction in CNS aging. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：265 / 272

页数：8

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