Sasanquol, a 3,4-seco-triterpene alcohol from sasanqua oil, and its anti-inflammatory effect

被引：22

作者：

Akihisa, T

Yasukawa, K

Kimura, Y

Yamanouchi, S

Tamura, T

机构：

[1] Nihon Univ, Coll Sci & Technol, Chiyoda Ku, Tokyo 101, Japan

[2] Nihon Univ, Coll Pharm, Funabashi, Chiba 274, Japan

来源：

PHYTOCHEMISTRY | 1998年 / 48卷 / 02期

关键词：

Camellia sasanqua; Theaceae; seed oil; seco-triterpene alcohol; sasanquol; antioedema; TPA-induced ear oedema;

D O I：

10.1016/S0031-9422(97)01107-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel 3,4-seco-triterpene alcohol, named sasanquol, was isolated from the non-saponifiable lipid of sasanqua oil from the seeds of Camellia sasanqua. Its structure was established to be 3,4-seco-D:B-friedobacchara-4,21-dien-3-ol by spectroscopic methods. This is the first example of naturally occurring triterpene with a D:B-friedobaccharane skeleton. The 50% inhibitory dose of this compound against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear inflammation (1 mu g per ear) in mice was 0.4 mg per ear. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：301 / 305

页数：5

共 22 条

[1] Triterpene alcohols from the flowers of compositae and their anti-inflammatory effects [J].