One-pot multicomponent diastereoselective synthesis of novel dihydro-1H-furo[2,3-c]pyrazoles

被引：8

作者：

Tangeti, Venkata Swamy ^{[1
]}

Prasad, G. V. Siva ^{[1
]}

Panda, Jagadeesh ^{[2
]}

Varma, K. Ramesh ^{[3
]}

机构：

[1] Raghu Engn Coll, Vishakhapatnam, India

[2] Raghu Coll Pharm, Vishakhapatnam, India

[3] Sri Venkateswara Univ, Tirupati, India

来源：

SYNTHETIC COMMUNICATIONS | 2016年 / 46卷 / 10期

关键词：

Dihydrofuro[1,2-b]pyrazole; microwave synthesis; multicomponent; solvent free; 3-COMPONENT SYNTHESIS; ORGANIC-SYNTHESIS; CHEMISTRY; DRUGS;

D O I：

10.1080/00397911.2016.1174781

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method was developed for the diastereoselective synthesis of novel fused dihydro-1H-furo[2,3-c]pyrazole by a one-pot, four-component reaction of beta-keto ester, hydrazine, aromatic aldehyde, and pyridinium ylide in the presence of triethylamine under microwave irradiation in solvent-free conditions in good yields. The merits of this cascade Knoevenagel condensation/Michael addition/cyclization sequence include its high atom economy, good yields, and efficiency of producing three new bonds (two C-C and one C-O) and two stereocenters in a single operation.

引用

页码：878 / 884

页数：7

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