Short syntheses of the indole alkaloids alocasin A, scalaridine A, and hyrtinadine A-B

被引：21

作者：

Ansari, Nurul H. ^{[1
]}

Soderberg, Bjorn C. G. ^{[1
]}

机构：

[1] W Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA

来源：

TETRAHEDRON | 2016年 / 72卷 / 29期

基金：

美国国家科学基金会;

关键词：

N-heterocyclization; Palladium-catalyzed; Indole; Alkaloid synthesis; WATER MARINE SPONGE; PALLADIUM-CATALYZED SYNTHESIS; CROSS-COUPLING REACTIONS; FORMAL TOTAL-SYNTHESIS; BIS(INDOLE) ALKALOIDS; BISINDOLE ALKALOIDS; HAMACANTHIN CLASSES; TOPSENTIN; DRAGMACIDIN; INHIBITORS;

D O I：

10.1016/j.tet.2016.05.057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Expedient syntheses of the indole alkaloids alocasin A, scalaridine A, and hyrtinadine A-B are presented. All four natural products contain one or two 5-hydroxyindolyl units. Three palladium catalyzed reactions, an alkyne hydrostannylation, a Kosugi-Migita-Stille cross coupling and a reductive N-heterocyclization are the key steps in the syntheses. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：4214 / 4221

页数：8

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