Clinical profiles of subjects with subcortical leukomalacia and border-zone infarction revealed by MR

Clinical profiles of 13 children with subcortical leukomalacia and border-zone infarction revealed by MR were analysed. The causes of brain damage were neonatal asphyxia, hypoglycaemia, circulatory disturbance associated with congenital heart diseases, and other perinatal events in five, three, two and three, respectively. Severe, moderate and mild mental retardation were present in three, five and five, respectively. Of the seven children who could walk alone, six had ataxia and one spastic diplegia; the remaining six manifested truncal instability. The ataxia was deduced to have resulted from cerebral lesions.