Tolerance of Benznidazole in Treatment of Chagas' Disease in Adults

被引：140

作者：

Pinazo, Maria-Jesus ^{[1
]}

Munoz, Jose ^{[1
]}

Posada, Elizabeth ^{[1
]}

Lopez-Chejade, Paulo ^{[2
]}

Gallego, Montserrat ^{[2
]}

Ayala, Edgar ^{[3
]}

del Cacho, Elena ^{[4
]}

Soy, Dolors ^{[4
]}

Gascon, Joaquim ^{[1
]}

机构：

[1] Hosp Clin Barcelona, Barcelona Ctr Int Hlth Res CRESIB, Trop Dis Sect, E-08036 Barcelona, Spain

[2] Univ Barcelona, Fac Farm, Parasitol Lab, E-08028 Barcelona, Spain

[3] Ctr Int Hlth Res CRESIB, Barcelona 08036, Spain

[4] Hosp Clin Barcelona, Dept Pharmacol, E-08036 Barcelona, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 11期

关键词：

ETIOLOGIC TREATMENT; EFFICACY; TRIAL;

D O I：

10.1128/AAC.00537-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Chagas' disease is an emerging public health problem in areas where the disease is not endemic. Treatment with benznidazole has shown efficacy in the acute stage of the disease, but its efficacy in the chronic stage remains controversial, and unwanted side effects are more frequent and severe in adults than in children. This study describes the profile of side effects of benznidazole in a cohort of Trypanosoma cruzi-infected patients in a European country.

引用

页码：4896 / 4899

页数：4

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