Non-invasive assessment of plaque morphology and remodeling in mildly stenotic coronary segments: comparison of 16-slice computed tomography and intravascular ultrasound

被引:110
作者
Schoenhagen, P
Tuzcu, EM
Stillman, AE
Moliterno, DJ
Halliburton, SS
Kuzmiak, SA
Kasper, JM
Magyar, WA
Lieber, ML
Nissen, SE
White, RD
机构
[1] Cleveland Clin Fdn, Sect Cardiovasc Imaging, Dept Radiol, Cleveland, OH 44195 USA
[2] Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA
[3] Cleveland Clin Fdn, Dept Biostat & Epidemiol, Cleveland, OH 44195 USA
关键词
coronary artery disease; multi-slice computed tomography; intravascular ultrasound;
D O I
10.1097/00019501-200309000-00007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Non-invasive identification and characterization of mildly stenotic atherosclerotic lesions is an increasingly important focus of coronary imaging. Design We examined the accuracy of multi (16)-slice computed tomography (MSCT) for imaging of these lesions in comparison with intravascular ultrasound (IVUS). Materials Mildly stenotic segments of the left coronary artery were identified by coronary angiography and analyzed using IVUS and contrast-enhanced MSCT. Independent reviewers evaluated the accuracy of MSCT for presence, composition and distribution of atherosclerotic plaque and remodeling response in comparison to IVUS using receiver operating characteristic (ROC) data analysis. Results Of 46 segments in 14 patients, diagnostic characterization by MSCT was possible in 37 (80.4%) segments. In these segments the accuracy of MSCT for identifying plaque presence, calcification, distribution and positive remodeling was consistently greater than 0.90 (reader 1) and 0.87 (reader 2). Conclusion State-of-the-art MSCT can accurately identify mildly stenotic coronary atherosclerosis and provide an assessment of morphology and remodeling response. (C) 2003 Lippincott Williams Wilkins.
引用
收藏
页码:459 / 462
页数:4
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