Comparison of vaccine-induced thrombotic events between ChAdOx1 nCoV-19 and Ad26.COV.2.S vaccines

被引：37

作者：

Hwang, Jimin ^{[1
]}

Lee, Se Bee ^{[2
]}

Lee, Seung Won ^{[3
]}

Lee, Min Ho ^{[4
]}

Koyanagi, Ai ^{[5
,6
]}

Jacob, Louis ^{[5
,7
,8
]}

Tizaoui, Kalthoum ^{[9
]}

Yon, Dong Keon ^{[10
]}

Shin, Jae Il ^{[11
]}

Smith, Lee ^{[12
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[2] Ulsan Univ, Coll Med, Seoul, South Korea

[3] Sejong Univ, Coll Software Convergence, Dept Data Sci, Seoul, South Korea

[4] Yonsei Univ, Coll Med, Seoul, South Korea

[5] Univ Barcelona, Fundacio St Joan Deu, Parc Sanitari St Joan Deu CIBERSAM, Barcelona, Spain

[6] ICREA, Pg Lluis Companys 23, Barcelona, Spain

[7] Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain

[8] Univ Versailles St Quentin En Yvelines, Fac Med, Montigny Le Bretonneux, France

[9] Tunis El Manar Univ, Sci Fac Tunis, Lab Microoranismes & Act Biomol, Tunis, Tunisia

[10] Seoul Natl Univ, Seoul Natl Univ Hosp, Coll Med, Dept Pediat, Seoul, South Korea

[11] Yonsei Univ, Coll Med, Dept Pediat, 50 Yonsei Ro,CPO Box 8044, Seoul 120752, South Korea

[12] Anglia Ruskin Univ, Cambridge Ctr Sport & Exercise Sci, Cambridge, England

来源：

JOURNAL OF AUTOIMMUNITY | 2021年 / 122卷

关键词：

Vaccine-induced thrombotic thrombocytopenia; Thrombotic thrombocytopenia syndrome; Adenoviral vector vaccine; COVID-19; vaccine; Cerebral venous thrombosis;

D O I：

10.1016/j.jaut.2021.102681

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cerebral venous thrombosis (CVT) events have been reported after vaccination with adenoviral COVID-19 vector vaccines. This study aimed to compare the clinical presentations and courses of vaccine-induced thrombotic thrombocytopenia (VITT) between the two adenoviral vector vaccines, Ad26.COV.2.S (Janssen/Johnson & Johnson) and ChAdOx1 nCoV-19 (Astra-Zeneca). We found that CVT after Ad26.COV.2.S vaccination presents later with similar symptoms compared to CVT after administration of ChAdOx1 nCoV-19, albeit with more thrombosis and intracerebral hemorrhage, lower D-dimer and aPTT levels but similar mortality. These findings could help guide clinical assessment and management of CVT after COVID-19 vaccination.

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