A Phytophthora effector recruits a host cytoplasmic transacetylase into nuclear speckles to enhance plant susceptibility

被引：60

作者：

Li, Haiyang ^{[1
,2
]}

Wang, Haonan ^{[1
,2
]}

Jing, Maofeng ^{[1
,2
]}

Zhu, Jinyi ^{[1
,2
]}

Guo, Baodian ^{[1
,2
]}

Wang, Yang ^{[1
,2
]}

Lin, Yachun ^{[1
,2
]}

Chen, Han ^{[1
,2
]}

Kong, Liang ^{[1
,2
]}

Ma, Zhenchuan ^{[1
,2
]}

Wang, Yan ^{[1
,2
]}

Ye, Wenwu ^{[1
,2
]}

Dong, Suomeng ^{[1
,2
]}

Tyler, Brett ^{[3
,4
]}

Wang, Yuanchao ^{[1
,2
]}

机构：

[1] Nanjing Agr Univ, Dept Plant Pathol, Nanjing, Jiangsu, Peoples R China

[2] Minist Educ, Key Lab Integrated Management Crop Dis & Pests, Nanjing, Jiangsu, Peoples R China

[3] Oregon State Univ, Ctr Genome Res & Biocomp, Corvallis, OR 97331 USA

[4] Oregon State Univ, Dept Bot & Plant Pathol, Corvallis, OR 97331 USA

来源：

ELIFE | 2018年 / 7卷

基金：

中国国家自然科学基金;

关键词：

HISTONE ACETYLTRANSFERASES; COCHLIOBOLUS-CARBONUM; ARABIDOPSIS-THALIANA; PATHOGEN EFFECTORS; EPIGENETIC CONTROL; FUNGAL PATHOGENS; GENE-EXPRESSION; RXLR EFFECTOR; HC-TOXIN; IMMUNITY;

D O I：

10.7554/eLife.40039

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oomycete pathogens secrete host cell-entering effector proteins to manipulate host immunity during infection. We previously showed that PsAvh52, an early-induced RxLR effector secreted from the soybean root rot pathogen, Phytophthora sojae, could suppress plant immunity. Here, we found that PsAvh52 is required for full virulence on soybean and binds to a novel soybean transacetylase, GmTAP1, in vivo and in vitro. PsAvh52 could cause GmTAP1 to relocate into the nucleus where GmTAP1 could acetylate histones H2A and H3 during early infection, thereby promoting susceptibility to P. sojae. In the absence of PsAvh52, GmTAP1 remained confined to the cytoplasm and did not modify plant susceptibility. These results demonstrate that GmTAP1 is a susceptibility factor that is hijacked by PsAvh52 in order to promote epigenetic modifications that enhance the susceptibility of soybean to P. sojae infection.

引用

页数：23

共 55 条

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