This Classic Article is a reprint of the original work by J. Wolff, On the Significance of the Architecture of the Spongy Substance for the Question of Bone Growth. An accompanying biographical sketch of Georg Hermann von Meyer and his relationship with Dr. Wolff is available at DOI 10.1007/s11999-011-2040-6. The Classic Article is (C) 1869. The Classic Article is A (c) 1869 and is reprinted from Wolff J. On the significance of the architecture of the spongy substance for the question of bone growth [Ueber die Bedeutung der Architectur der Spongiosen Sunstanz fur de Frage Vom Knochenwachsthu. Vorlaufge Mettheilung]. Centralblatt fur die meichinschen Wissenschaften. 1869;54:849-851.