Synthesis, Structure and Antitumor Activity of Organotin 1,1′-Methylenebis(1H-pyrazole-4-carboxylates)

Four triorganotin 1,1'-methylenebis(1H-pyrazole-4-carboxylates) (CH2(PzCO(2)SnR(3))(2), R=Ph (1), cyclohexyl (2), Et (3), n-Bu (4)) have been synthesized via the reaction of R3SnOH or (R3Sn)(2)O with 1,1'-methylenebis(1H-pyrazole-4-carboxylic acid). All these complexes were characterised by elemental analysis, IR and multinuclear NAIR (H-1, C-13 and Sn-119). The structures of 1 and 3 have been confirmed by the, X-ray single crystal diffraction analysis, suggesting that the pyrazoyl nitrogen atoms don't participate in coordination to the tin atoms, and the carboxylate groups show considerably different coordination modes in these two complexes. In addition, complex 1 only shows a dinuclear structure, while complex 3 forms a 2D-coordination polymer with 32-membered macrocyclic units through the bridging carboxylate oxygen atoms. The cytotoxic activity of these complexes for MCF-7 and A549 cells was tested, showing that they displayed good cytotoxicities for these two cells in, vitro. CC DC: 1949278, 1; 1949279, 3.