Yeast: An Experimental Organism for 21st Century Biology

被引：380

作者：

Botstein, David ^{[1
]}

Fink, Gerald R. ^{[2
,3
]}

机构：

[1] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

[2] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02139 USA

[3] MIT, Cambridge, MA 02139 USA

来源：

GENETICS | 2011年 / 189卷 / 03期

关键词：

SACCHAROMYCES-CEREVISIAE GENOME; PROTEIN-PROTEIN INTERACTIONS; GENE-EXPRESSION; BUDDING YEAST; FUNCTIONAL-CHARACTERIZATION; TRANSCRIPTION FACTORS; ADAPTIVE EVOLUTION; DNA ASSOCIATION; GLOBAL ANALYSIS; DUPLICATION;

D O I：

10.1534/genetics.111.130765

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In this essay, we revisit the status of yeast as a model system for biology. We first summarize important contributions of yeast to eukaryotic biology that we anticipated in 1988 in our first article on the subject. We then describe transformative developments that we did not anticipate, most of which followed the publication of the complete genomic sequence of Saccharomyces cerevisiae in 1996. In the intervening 23 years it appears to us that yeast has graduated from a position as the premier model for eukaryotic cell biology to become the pioneer organism that has facilitated the establishment of the entirely new fields of study called "functional genomics" and "systems biology." These new fields look beyond the functions of individual genes and proteins, focusing on how these interact and work together to determine the properties of living cells and organisms.

引用

页码：695 / 704

页数：10

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