Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning

被引：52

作者：

Crisafulli, Antonio ^{[1
]}

Pagliaro, Pasquale ^{[2
]}

Roberto, Silvana ^{[1
]}

Cugusi, Lucia ^{[3
]}

Mercuro, Giuseppe ^{[1
]}

Lazou, Antigone ^{[4
]}

Beauloye, Christophe ^{[5
,6
]}

Bertrand, Luc ^{[5
]}

Hausenloy, Derek J. ^{[7
,8
,9
,10
,11
]}

Aragno, Manuela ^{[2
]}

Penna, Claudia ^{[2
]}

机构：

[1] Univ Cagliari, Dept Med Sci & Publ Hlth, I-09124 Cagliari, Italy

[2] Univ Torino, Dept Clin & Biol Sci, I-10043 Obassano, TO, Italy

[3] Univ Sassari, Dept Biomed Sci, I-07100 Sassari, Italy

[4] Aristotle Univ Thessaloniki, Sch Biol, Thessaloniki 54124, Greece

[5] UCLouvain, IREC Inst, Pole Cardiovasc Res, B-1200 Brussels, Belgium

[6] Clin Univ St Luc, Div Cardiol, B-1200 Brussels, Belgium

[7] Duke Natl Univ Singapore, Cardiovasc & Metab Disorders Program, Singapore 169857, Singapore

[8] Natl Heart Ctr Singapore, Natl Heart Res Inst Singapore, Singapore 169609, Singapore

[9] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore 119228, Singapore

[10] UCL, Hatter Cardiovasc Inst, London WC1E 6HX, England

[11] Asia Univ, Coll Med & Hlth Sci, Cardiovasc Res Ctr, Taichung 41354, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 08期

基金：

英国医学研究理事会;

关键词：

diabetic cardiomyopathy; hyperglycemia; ischemia; reperfusion injury; metabolism; mitochondria; remote conditioning; exercise; PERCUTANEOUS CORONARY INTERVENTION; ACUTE MYOCARDIAL-INFARCTION; BYPASS GRAFT-SURGERY; PHYSICAL-ACTIVITY; RISK-FACTORS; INSULIN-RESISTANCE; GLYCEMIC CONTROL; CARDIOVASCULAR-DISEASE; MOLECULAR-MECHANISMS; CARDIAC PROTECTION;

D O I：

10.3390/ijms21082896

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic syndrome, diabetes, and ischemic heart disease are among the leading causes of death and disability in Western countries. Diabetic cardiomyopathy is responsible for the most severe signs and symptoms. An important strategy for reducing the incidence of cardiovascular disease is regular exercise. Remote ischemic conditioning has some similarity with exercise and can be induced by short periods of ischemia and reperfusion of a limb, and it can be performed in people who cannot exercise. There is abundant evidence that exercise is beneficial in diabetes and ischemic heart disease, but there is a need to elucidate the specific cardiovascular effects of emerging and unconventional forms of exercise in people with diabetes. In addition, remote ischemic conditioning may be considered among the options to induce beneficial effects in these patients. The characteristics and interactions of diabetes and ischemic heart disease, and the known effects of exercise and remote ischemic conditioning in the presence of metabolic syndrome and diabetes, are analyzed in this brief review.

引用

页数：22

共 157 条

[1] Exercise-induced changes in neuropeptide Y, noradrenaline and endothelin-1 levels in young people with type I diabetes [J].