Long-term follow-up of tuberculosis-destroyed lung patients after surgical treatment

被引:7
作者
Ruan, Hongyun [1 ]
Liu, Fangchao [2 ]
Li, Yunsong [3 ]
Wang, Yuxuan [3 ]
Hou, Dongdong [4 ]
Yang, Xinting [5 ]
Liu, Bin [1 ]
Ma, Teng [1 ]
Liu, Zhidong [3 ]
机构
[1] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Cellular & Mol Biol, 9 Bei Guan St, Beijing 101149, Peoples R China
[2] Capital Med Univ, Beijing TB & Thorac Tumor Res Inst, Beijing Chest Hosp, Sci & Technol Off, Beijing, Peoples R China
[3] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept Thorac Surg, 9 Bei Guan St, Beijing 101149, Peoples R China
[4] Peking Univ, Dept Med Oncol, Shougang Hosp, Beijing, Peoples R China
[5] Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Dept TB, Beijing, Peoples R China
关键词
Tuberculosis; Damaged lung; Surgical treatment; Modified British medical research council (mMRC); Living status; PNEUMONECTOMY; SURGERY; MORTALITY; MORBIDITY; EFFICACY;
D O I
10.1186/s12890-022-02139-z
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background To monitor dypsnea and mortality at 5 and 10 years, respectively, after surgical treatment of tuberculosis-destroyed lung (TDL) patients. Methods TDL patients treated surgically at Beijing Chest Hospital from November 2007 to June 2019 were monitored in this observational study. Follow-up assessments of respiratory function indicators and survival conducted 5 and 10 years post-surgery led to patient grouping based on mMRC score into a dyspnea group (mMRC >= 1) and a non-dyspnea group (mMRC = 0). Cox regression analysis detected effects of patient demographics, clinical characteristics, surgical factors and respiratory function on 5 year post-surgical survival. Results By study completion (June 30, 2020), 32 of 104 patients were lost and 72 completed follow-up for a study total of 258.9 person-years. 45 patients (62.5%, 45/72) had mMRC scores of 0, while 12 (16.7%, 12/72), 21 (36.2%, 21/58) and 27 (60.0%, 27/45) patients exhibited dyspnea by 1, 3 and 5 years post-surgery, respectively. Low lung carbon monoxide diffusion score (DLCO% pred) and scoliosis contributed to dyspnea occurrence. Conclusions Most TDL patients lacked subjective dyspnea signs post-surgery, while dyspnea rates increased with time. Preoperative low lung diffusion function and Scoliosis were associated with factors for postoperative dyspnea. Surgical treatment increased TDL patient survival overall.
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页数:8
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