Harnessing the microbiome to restore immunotherapy response

被引：10
|
作者：
Bullman, Susan [1 ]
Eggermont, Alexander [2 ,3 ]
Johnston, Christopher D. [4 ]
Zitvogel, Laurence [5 ,6 ,7 ,8 ]
机构：
[1] Fred Hutchinson Canc Res Ctr, Human Biol Div, 1124 Columbia St, Seattle, WA 98104 USA
[2] Univ Med Ctr Utrecht, Clin & Translat Immunotherapy, Utrecht, Netherlands
[3] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands
[4] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA
[5] Univ Paris Saclay, Fac Med, Paris, France
[6] INSERM, U1015, Paris, France
[7] Equipe Labellisee Ligue Canc, Paris, France
[8] Ctr Clin Invest Biotherapies Canc BIOTHERIS, Paris, France
来源：
NATURE CANCER | 2021年 / 2卷 / 12期
关键词：
BLOCKADE;
D O I：
10.1038/s43018-021-00300-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Despite the profound clinical success of immune-checkpoint inhibitors, their effectiveness is limited by intrinsic and acquired resistance. Bullman, Zitvogel and colleagues provide their views on two clinical trials modulating the microbiome of immunotherapy-resistant patients with melanoma via transplantation of fecal microbiota from patients who responded to immunotherapy.
引用
收藏
页码：1301 / 1304
页数：4
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