2-Pyridinoformamide-derived thiosemicarbazones and their iron(III) complexes: Potential antineoplastic activity

被引：28

作者：

Graminha, Angelica E. ^{[2
]}

Vilhena, Felipe S. ^{[1
]}

Batista, Alzir A. ^{[2
]}

Louro, Sonia R. W. ^{[3
]}

Ziolli, Roberta L. ^{[1
]}

Teixeira, Leticia R. ^{[1
]}

Beraldo, Heloisa ^{[4
]}

机构：

[1] Pontificia Univ Catolica Rio de Janeiro, Dept Quim, BR-22453900 Rio De Janeiro, Brazil

[2] Univ Fed Sao Carlos, Dept Quim, BR-1365905 Sao Carlos, SP, Brazil

[3] Pontificia Univ Catolica Rio de Janeiro, Dept Fis, BR-22453900 Rio De Janeiro, Brazil

[4] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil

来源：

POLYHEDRON | 2008年 / 27卷 / 02期

关键词：

2-pyridineformamide thiosemicarbazones; iron complexes; cytoxicity; Artemia salina;

D O I：

10.1016/j.poly.2007.10.008

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The iron(III) complexes [Fe(2Am4DH)(2)]Cl (1), [Fe(2Am4Me)(2)]Cl (2) and [Fe(2Am4Et)(2)]Cl (3) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me) and N(4)-ethyl (H2Am4Et) derivatives were obtained and characterized by means microanalyses, infrared and EPR spectra. The electrochemical behavior of the complexes was investigated. The thiosemicarbazones and complexes (1) and (2) presented toxicity against Artemia salina at low concentrations. Since this bioassay has a good correlation with cytotoxic activity in human solid tumors, the studied compounds present potential pharmacological applications. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：547 / 551

页数：5

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